Transcriptional changes induced by the tumor dormancy-associated microRNA-190

Autor: Edward A. Rietman, Christine Briggs, Afshin Beheshti, Kathleen P. Wilkie, Lili Ma, Lynn Hlatky, Nava Almog
Rok vydání: 2013
Předmět:
tumor dormancy
Transcription
Genetic
Transplantation
Heterologous
Mice
SCID
Biology
Biochemistry
Mice
03 medical and health sciences
0302 clinical medicine
transcriptional reprogramming
Interferon
Cell Line
Tumor
Neoplasms
osteosarcoma
microRNA
Genetics
medicine
Animals
Humans
Proto-Oncogene Proteins c-cbl
Transcription factor
Adaptor Proteins
Signal Transducing
Cell Proliferation
030304 developmental biology
0303 health sciences
Gene Expression Profiling
glioblastoma
RNA-Binding Proteins
Cancer
medicine.disease
Molecular biology
3. Good health
Gene Expression Regulation
Neoplastic
MicroRNAs
030220 oncology & carcinogenesis
Dystrophin-Associated Proteins
Cancer cell
Cancer research
Osteosarcoma
Dormancy
Apoptosis Regulatory Proteins
Reprogramming
Transcription Factors
Research Paper
Biotechnology
medicine.drug
Zdroj: Transcription
ISSN: 2154-1272
2154-1264
Popis: Tumor dormancy is a highly prevalent stage in cancer progression. We have previously generated and characterized in vivo experimental models of human tumor dormancy in which micro-tumors remain occult until they spontaneously shift into rapid tumor growth. We showed that the dormant micro-tumors undergo a stable microRNA (miRNA) switch during their transition from dormancy to a fast-growing phenotype and reported the identification of a consensus signature of human tumor dormancy-associated miRNAs (DmiRs). miRNA-190 (miR-190) is among the most upregulated DmiRs in all dormant tumors analyzed. Upregulation of miR-190 led to prolonged tumor dormancy in otherwise fast-growing glioblastomas and osteosarcomas. Here we investigate the transcriptional changes induced by miR-190 expression in cancer cells and show similar patterns of miR-190 mediated transcriptional reprogramming in both glioblastoma and osteosarcoma cells. The data suggests that miR-190 mediated effects rely on an extensive network of molecular changes in tumor cells and that miR-190 affects several transcriptional factors, tumor suppressor genes and interferon response pathways. The molecular mechanisms governing tumor dormancy described in this work may provide promising targets for early prevention of cancer and may lead to novel treatments to convert the malignant tumor phenotype into an asymptomatic dormant state.
Databáze: OpenAIRE
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