Immunogenicity of cell walls from various mycobacteria against airborne tuberculosis in mice
| Autor: | W. Brehmer, Edgar Ribi, Robert L. Anacker |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Tuberculosis
Mutant Virulence Spleen Infection and Immunity Biology Microbiology complex mixtures Mycobacterium Cell wall Mice Cell Wall medicine Animals Molecular Biology Strain (chemistry) Immunogenicity Mycobacterium tuberculosis medicine.disease Virology Mycobacterium bovis medicine.anatomical_structure BCG Vaccine Female BCG vaccine |
| Zdroj: | Journal of bacteriology. 95(6) |
| ISSN: | 0021-9193 |
| Popis: | Protective potency of oil-treated cell walls of various mycobacteria against airborne infection of mice with a few cells of Mycobacterium tuberculosis H37Rv was compared with that of viable BCG. Although less potent than BCG cell walls, the cell walls of atypical mycobacteria of Runyon's groups I to IV protected against challenge by aerosol to some degree. Protection afforded by cell walls of H37Rv and of the avirulent mutants H37Ra and Washington II was comparable to that provided by BCG cell walls. However, cell walls of a highly virulent strain of M. bovis (Bovinus I) provided the best protection yet achieved. Present evidence suggests that protective substances are shared by all mycobacteria but in differing amounts; the relationship between virulence and immunogenicity has yet to be clarified. |
| Databáze: | OpenAIRE |
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