Effect of estrogen on electroretinographic responses in streptozotocin-induced diabetic female rats
| Autor: | Shunsuke Tsutsumi, Yoshinobu Iwaki, Chiaki Yamada, Kazunari Sugihara, Haruhiro Yamashita |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
medicine.medical_specialty endocrine system diseases medicine.drug_class Ovariectomy Ovary Cataract Retina Corneal Diseases Diabetes Mellitus Experimental Cellular and Molecular Neuroscience chemistry.chemical_compound Diabetes mellitus Internal medicine medicine Electroretinography Animals Rats Long-Evans Diabetic Retinopathy medicine.diagnostic_test business.industry Body Weight nutritional and metabolic diseases Retinal Estrogens Diabetic retinopathy Long evans medicine.disease Streptozotocin Sensory Systems Rats Ophthalmology medicine.anatomical_structure Endocrinology chemistry Estrogen Female sense organs business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Experimental eye research. 90(5) |
| ISSN: | 1096-0007 |
| Popis: | The aim of this study is to investigate the effects of estrogen on functional changes in the retinas of streptozotocin (STZ)-induced diabetic rats by using an electroretinography. Female rats were randomly divided into four treatment groups: (1) Control (sham operation and vehicle administration); (2) STZ (sham operation and STZ administration); (3) OVX (ovariectomy and vehicle administration); and (4) OVX + STZ (ovariectomy and STZ administration). Full-field electroretinograms (ERGs) were recorded before OVX and STZ administration and 4 and 12 weeks after STZ administration. At 4 weeks after STZ administration, although there were no differences in the STZ and OVX groups compared with the Control group, the amplitude of the cone-response was significantly lower in the OVX + STZ group than in the Control group (P = 0.013). At 12 weeks after STZ administration, this response showed a similar tendency in the STZ and the OVX + STZ groups. At 12 weeks after STZ administration, the implicit times of OP3 and OP4 and of the cone-response were significantly delayed in the STZ and OVX + STZ groups (OP3: P = 0.030 and 0.050, OP4: P = 0.0060 and 0.0053, cone-response: P = 0.014 and 0.039), compared with in the Control group. Thus, the retinal functions in STZ-induced diabetic female rats were aggravated by OVX. OVX-induced estrogen deficiency resulted in earlier changes in the amplitudes of cone-response, especially in the diabetes, although this is a transient effect and it is difficult to explain. Recognizing the early neurosensory change would enable a better understanding of the effect of estrogen in the retina. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect