Gene expression microarray classification using PCA-BEL
| Autor: | Ehsan Lotfi, Azita Keshavarz |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Computational complexity theory
Computer science Feature vector Health Informatics Machine learning computer.software_genre Sensitivity and Specificity Cross-validation Pattern Recognition Automated Neoplasms Biomarkers Tumor Humans Computer Simulation Oligonucleotide Array Sequence Analysis Models Statistical business.industry Microarray analysis techniques Gene Expression Profiling Reproducibility of Results Gene expression microarray Computer Science Applications Neoplasm Proteins Data Interpretation Statistical Pattern recognition (psychology) Principal component analysis Artificial intelligence business computer Curse of dimensionality Signal Transduction |
| Zdroj: | Computers in biology and medicine. 54 |
| ISSN: | 1879-0534 |
| Popis: | In this paper, a novel hybrid method is proposed based on Principal Component Analysis (PCA) and Brain Emotional Learning (BEL) network for the classification tasks of gene-expression microarray data. BEL network is a computational neural model of the emotional brain which simulates its neuropsychological features. The distinctive feature of BEL is its low computational complexity which makes it suitable for high dimensional feature vector classification. Thus BEL can be adopted in pattern recognition in order to overcome the curse of dimensionality problem. In the experimental studies, the proposed model is utilized for the classification problems of the small round blue cell tumors (SRBCTs), high grade gliomas (HGG), lung, colon and breast cancer datasets. According to the results based on 5-fold cross validation, the PCA-BEL provides an average accuracy of 100%, 96%, 98.32%, 87.40% and 88% in these datasets respectively. Therefore, they can be effectively used in gene-expression microarray classification tasks. The computational complexity of BEL model is O(n).BEL is a suitable model for high dimensional feature vector classification.In this paper, BEL is applied for the classification tasks of gene-expression microarray data.Proposed method improves the detection accuracy of SRBCT, HGG and lung cancer.Our method has been able to effect a 30.18% improvement on HGG classification. |
| Databáze: | OpenAIRE |
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