Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system
| Autor: | Jiechun Chen, Ruijie Chen, Jianchun Pan, Ying Xu, Miranda N. Reed, Gaowen Li, Lichao Chen, Lina Ruan, Meixi Zhang, Xupei Xie, Renye Wang, Qizhi Yan, Wu Huang |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Coumaric Acids Polyunsaturated Alkamides Monoamine oxidase Biological Availability Motor Activity Pharmacology Serotonergic Biochemistry Article Ferulic acid Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Alkaloids Neurochemical Piperidines Monoaminergic Animals Biogenic Monoamines Benzodioxoles Monoamine Oxidase Swimming Brain Chemistry Mice Inbred ICR Neurotransmitter Agents Depression Drug Synergism Antidepressive Agents Bioavailability Monoamine neurotransmitter Hindlimb Suspension chemistry Piperine Neurology (clinical) |
| Zdroj: | Metabolic Brain Disease. 30:1505-1514 |
| ISSN: | 1573-7365 0885-7490 |
| DOI: | 10.1007/s11011-015-9704-y |
| Popis: | The lifetime prevalence rate for major depressive disorder (MDD) is approximately 17 % for most developed countries around the world. Dietary polyphenols are currently used as an adjuvant therapy to accelerate the therapeutic efficacy on depression. Ferulic acid (FA) or 4-hydroxy-3-methoxy-cinnamic acid (Fig. 1a) is a main polyphenolic component of Chinese herb Radix Angelicae Sinensis, which is found to have antidepressant-like effects through regulating serotonergic and noradrenergic function. The present study examined the synergistic effect of low doses of FA combined with subthreshold dose of piperine, a bioavailability enhancer, on depression-like behaviors in mice, and investigated the possible mechanism. The administration of FA, even in the highest dose tested, reduced immobility time by 60 % in the tail suspension and forced swimming tests (TST and FST) in mice when compared to control. The maximal antidepressant-like effect of FA was obtained with 200 mg/kg. In addition, piperine only produced a weak antidepressant-like effect in the TST and FST. However, the evidence from the interaction analysis suggested a synergistic effect when low doses of FA were combined with a subthreshold dose of piperine. Further neurochemical evidence such as monoamine levels in the frontal cortex, hippocampus, and hypothalamus and measurements of monoamine oxidase activity also supported a synergistic effect of FA and piperine in the enhancement of monoaminergic function. This finding supports the concept that the combination strategy might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects. |
| Databáze: | OpenAIRE |
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