The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults

Autor: Pilar Galan, James R. Hébert, Mathilde Touvier, Nitin Shivappa, Chantal Julia, Emmanuelle Kesse-Guyot, Michael D. Wirth, Karen E. Assmann, Serge Hercberg, Moufidath Adjibade, Tasnime N. Akbaraly
Přispěvatelé: Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13), Conservatoire National des Arts et Métiers [CNAM] (CNAM), Université Sorbonne Paris Cité (USPC), University of South Carolina [Columbia], Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Department of Epidemiology and Public Health, University College of London [London] (UCL), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), French National Research Agency [ANR-05-PNRA-010], French Ministry of Health, Mederic, Sodexo, Ipsen, MGEN, Pierre Fabre, Sodexo, a food catering company, Ecole Doctorale Galilee, University of Paris 13, Sorbonne Paris Cite, US National Institute of Diabetes and Digestive and Kidney Diseases [R44DK103377], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Hôpital avicenne, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris 13 (UP13)-Hôpital Avicenne, Université Montpellier 2 - Sciences et Techniques (UM2)-École pratique des hautes études (EPHE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Avicenne
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Aging
medicine.medical_treatment
Medicine (miscellaneous)
Disease
dietary score
Antioxidants
law.invention
Healthy Aging
chemistry.chemical_compound
Cognition
Randomized controlled trial
law
Activities of Daily Living
Nutritional Epidemiology
ComputingMilieux_MISCELLANEOUS
Nutrition and Dietetics
Depression
Confounding
Middle Aged
Healthy Volunteers
3. Good health
nutrition
symbols
dietary inflammatory index
Female
France
Vitamin
medicine.medical_specialty
Pain
Placebo
03 medical and health sciences
symbols.namesake
Diabetes mellitus
Internal medicine
medicine
Humans
Poisson regression
Inflammation
030109 nutrition & dietetics
business.industry
Vitamin E
Social Support
healthy aging inflammation
Feeding Behavior
medicine.disease
Diet
chemistry
Chronic Disease
Dietary Supplements
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Journal of Nutrition
Journal of Nutrition, American Society for Nutrition, 2018, 148 (3), pp.437-444. ⟨10.1093/jn/nxx061⟩
ISSN: 0022-3166
DOI: 10.1093/jn/nxx061⟩
Popis: Background While low-grade chronic inflammation has been suggested as a major modulator of healthy aging (HA), no study has yet investigated the link between the inflammatory potential of the diet and multidimensional concepts of HA. Objective We aimed to evaluate the association between the inflammatory potential of the diet at midlife, as measured by the Dietary Inflammatory Index (DII), and HA assessed 13 y later. Methods We analyzed data from 2796 participants in the French Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) study aged 45-60 y at baseline (1994-1995) and initially free of diabetes, cardiovascular disease, and cancer. During the trial phase of the study (1994-2002), participants received either a placebo or a daily nutritional dose of antioxidant supplement (120 mg vitamin C, 6 mg β-carotene, 30 mg vitamin E, 100 μg Se, 20 mg Zn). HA was assessed in 2007-2009, and defined as having no major chronic disease, good physical and cognitive functioning, independence in daily activities, no depressive symptoms, good social health, good overall self-perceived health, and no function-limiting pain. The DII was calculated based on repeated baseline 24-h dietary records. Its association with HA was assessed by robust-error-variance Poisson regression, providing RR estimates. Results After adjustment for potential confounders, higher DII scores (reflecting a more proinflammatory diet), were associated with a decreased likelihood of HA: RRtertile 3/tertile 1 = 0.85 (95% CI: 0.74, 0.99); P-trend = 0.03. Secondary analyses revealed that this association was only significant among participants who had been in the placebo group during the trial phase: RRtertile 3/tertile 1 = 0.80 (95% CI: 0.64, 1.00); P-trend = 0.04. Conclusions This study suggests that a proinflammatory diet may lower the probability of overall HA. The SU.VI.MAX trial was registered at www.clinicaltrials.gov as NCT00272428.
Databáze: OpenAIRE
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