Clinically relevant phenotypes in chronic rhinosinusitis
| Autor: | Richard J. Harvey, Marina Neves Cavada, Jessica W. Grayson |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Rhinology
medicine.medical_specialty animal structures lcsh:Surgery Anti-Inflammatory Agents Disease Review 03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones Eosinophilic otorhinolaryngologic diseases Medicine Humans Sinusitis 030223 otorhinolaryngology Intensive care medicine Asthma Rhinitis business.industry Correction Endoscopy lcsh:RD1-811 respiratory system medicine.disease Phenotype Radiography Otorhinolaryngology 030220 oncology & carcinogenesis Chronic Disease Etiology Surgery business Airway |
| Zdroj: | Journal of Otolaryngology-Head & Neck Surgery Journal of Otolaryngology-Head and Neck Surgery, Vol 48, Iss 1, Pp 1-10 (2019) |
| ISSN: | 1916-0216 |
| Popis: | Background Chronic rhinosinusitis (CRS) is a complex disease that incorporates many different conditions. Currently, primary CRS is considered a disease of broad airway inflammation, however, the previous classification of CRS with and without nasal polyposis fails to adequately classify patients based upon their etiology of illness. Our aim with this review is discuss the clinical presentation, radiology, endoscopy, histopathology, and treatment algorithm of three different phenotypes of primary CRS: central compartment atopic disease, eosinophilic CRS, and non-eosinophilic CRS. Methods A narrative review of a tertiary rhinology center’s research themes and how they are applied to clinical protocols and practice was assessed. Discussion Diagnosis and treatment of upper and lower airway conditions become increasingly important as phenotypes and endotypes are being described. There are well-described therapies to treat the different phenotypes of CRS, based upon the presumed underlying cause of the inflammatory process. Research continues to shed more light on different endotypes and phenotypes of airway inflammation, however, clinical differentiation of CRS can be applied in clinic practice with three simple phenotypes of CRS. Understanding these different phenotypes and their etiologies allows for further management beyond the ‘maximum medical therapy and then surgery’ approach that has often been used in the management of CRS. |
| Databáze: | OpenAIRE |
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