Hypolipidemic, antiobesity and cardioprotective effects of sardinelle meat flour and its hydrolysates in high-fat and fructose diet fed Wistar rats
| Autor: | Moncef Nasri, Leticia Mora, Mohamed Hajji, Abdelfattah Elfeki, Kamel Jamoussi, Rim Nasri, Ola Abdelhedi, Fidel Toldrá, Ines Jemil, Rim Marrekchi |
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| Přispěvatelé: | Ministère de l’Enseignement Supérieur et de la Recherche Scientifique (Tunisie), Ministerio de Economía y Competitividad (España), European Commission, Consejo Superior de Investigaciones Científicas (España) |
| Rok vydání: | 2017 |
| Předmět: |
Fish Proteins
Male 0301 basic medicine medicine.medical_specialty Bacillus amyloliquefaciens Protein Hydrolysates Adipose tissue Fructose Fructose diet General Biochemistry Genetics and Molecular Biology Hydrolysate Hypolipidemic 03 medical and health sciences Oral administration Internal medicine Hyperlipidemia medicine High fat Animals Obesity Rats Wistar General Pharmacology Toxicology and Pharmaceutics Hypolipidemic Agents 030109 nutrition & dietetics biology Chemistry Antiobesity General Medicine Fermented sardinelle protein hydrolysates medicine.disease biology.organism_classification Dietary Fats Lipids Rats 030104 developmental biology Endocrinology Fermentation High caloric diet Cardioprotective Fish Flour |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2016.07.012 |
| Popis: | Aims: The present study aims to evaluate the antiobesity, hypolipidemic and cardioprotective effects of fermented sardinelle (Sardinella aurita) protein hydrolysates (FSPHs) produced with two proteolytic bacteria, Bacillus subtilis A26 (FSPH-A26) and Bacillus amyloliquefaciens An6 (FSPH-An6). Main methods: Wistar rats were fed during 10 weeks a standard laboratory diet, a high caloric diet (HCD) and a HCD coupled with the oral administration of sardinelle meat flour (SMF) or FSPHs. Key findings: HCD caused hyperlipidemia and increased body weight (BW). The daily oral administration of FSPHs or SMF reduced the total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-c) serum levels, and increased the level of high-density lipoprotein cholesterol (HDL-c). Nevertheless, FSPHs were found to be more efficient than SMF. FSPHs also lowered hepatic TC and TG content and decreased the pancreatic lipase activity. Further, the administration of FSPHs or SMF decreased the BW gain, the food intake and the relative epididymal adipose tissue weight. FSPHs exhibited a potent cardioprotective effect against heart attack, which was demonstrated by returning atherogenic indexes to their normal levels and the conservation of standard histological structure of the heart and aorta. Significance: The overall results indicate that FSPHs contained bioactive peptides which significantly attenuated hyperlipidemia, and might reduce the risk of cardiovascular disease (CVD) in rats fed HCD. This work was funded by the Ministry of Higher Education and Scientific Research-Tunisia. AGL2014-57367-R from MINECO and FEDER funds, and JAEDOC-CSIC post-doctoral contract of L.M. cofounded by the European Social Found are acknowledged. MALDI-TOF analysis was carried out by in the SCSIE University of Valencia Proteomics Unit (Spain), a member of ISCIII ProteoRed Proteomics Platform. |
| Databáze: | OpenAIRE |
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