Clinical significance of antiproteinase 3 antibody positivity in cANCA-positive patients
| Autor: | Bernard Lauwerys, Jean-Pierre Devogelaer, Frédéric Houssiau, Michel Jadoul, Jean-Paul Tomasi, Chantal Lefebvre, Vincent Van Pesch |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Myeloblastin Context (language use) Enzyme-Linked Immunosorbent Assay Autoantigens Severity of Illness Index Antibodies Antineutrophil Cytoplasmic Diagnosis Differential Rheumatology Internal medicine medicine Humans Clinical significance cardiovascular diseases Anti-neutrophil cytoplasmic antibody Autoantibodies Retrospective Studies biology business.industry Serine Endopeptidases Granulomatosis with Polyangiitis General Medicine medicine.disease Cytoplasmic staining Antiproteinase 3 antibody Immunology biology.protein Antibody business Vasculitis Biomarkers |
| Zdroj: | Clinical rheumatology. 18(4) |
| ISSN: | 0770-3198 |
| Popis: | We addressed the clinical significance of antiproteinase 3 (anti-PR3) antibody (Ab) positivity by reviewing the files of 79 patients whose serum contained antineutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (cANCA) and had been tested for anti-PR3 reactivity. Vasculitis was present in most (22/35) cANCA+ PR3+ patients but in only a few (5/44) cANCA+ PR3- patients, thereby suggesting that anti-PR3 Ab positivity in cANCA+ patients is more indicative of vasculitis than cANCA positivity alone. Noteworthy, one-third of cANCA+ PR3+ patients -- those with anti-PR3 Ab titres lower than 100 U/ml -- did not suffer from vasculitis. Anti-PR3 reactivity in vasculitis patients was only weakly associated with Wegener's granulomatosis (WG), as nine out of 22 cANCA+ PR3+ vasculitis patients (41%) did not fulfil the ACR classification criteria for WG. There was no correlation between anti-PR3 Ab titres and disease activity at diagnosis. However, titres measured when patients were in remission were much lower than initial values. Taken together, our results indicate that anti-PR3 Ab positivity should be interpreted in its clinical context. |
| Databáze: | OpenAIRE |
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