Effect of garlic oil on ethanol induced gastric ulcers in rats
| Autor: | Prem Kumar Khosla, V. K. Bhargava, R. S. Karan |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Garlic Oil Pharmacology Ulcer index Lipid peroxidation chemistry.chemical_compound medicine Animals Plant Oils Stomach Ulcer Rats Wistar Garlic chemistry.chemical_classification Reactive oxygen species Dose-Response Relationship Drug Ethanol biology Superoxide Dismutase food and beverages Anti-Ulcer Agents Allium sativum digestive system diseases Enzyme assay Rats Biochemistry chemistry Gastric Mucosa Catalase biology.protein Lipid Peroxidation Phytotherapy |
| Zdroj: | Phytotherapy Research. 18:87-91 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.1349 |
| Popis: | Garlic oil was evaluated for gastroprotective activity against ethanol induced ulcers. Reactive oxygen species are involved in the pathogenesis of these ulcers. The possible involvement of garlic oil in restraining the oxidation process produced in gastric tissue was also investigated. The ulcer index, lipid peroxidation and antioxidant enzyme activity (GPx, catalase, SOD) were determined. Pretreatment with garlic oil in doses of 0.25 and 0.5 mg/kg, 30 min before administration of ethanol (1 mL of 100%) caused a decrease in ulcer index and lipid peroxidation and ameliorated the decrease in antioxidant enzyme levels caused by ethanol. The result suggests that garlic oil possesses antioxidant properties and provides protection against ethanol induced gastric injury. |
| Databáze: | OpenAIRE |
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