Behavioral and biochemical evidence for serotonergic actions of tetrahydro-beta-carbolines
| Autor: | Patrick M. Callahan, Francis J. White, Erik B. Nielsen, Alice M. Holohean, James B. Appel |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Agonist
Male Serotonin Indoles medicine.drug_class Pharmacology Pizotifen Serotonergic General Biochemistry Genetics and Molecular Biology Discrimination Learning Dopamine medicine Haloperidol Animals General Pharmacology Toxicology and Pharmaceutics Behavior Animal Chemistry Antagonist Rats Inbred Strains General Medicine Rats Lysergic Acid Diethylamide Antagonism medicine.drug Carbolines |
| Zdroj: | Life sciences. 31(22) |
| ISSN: | 0024-3205 |
| Popis: | In two groups of rats trained to discriminate LSD (0.1 mg/kg or 0.24 mg/kg) from saline, tetrahydro-β-carboline (THBC; 1–12 mg/kg as free base) and its derivative 6-methoxy-THBC (1–12 mg/kg as free base) substituted partially for LSD. The substitution of THBC for 0.1 mg/kg of LSD was analyzed further with antagonism tests in 16 animals and was attenuated by the serotonin (5-HT) antagonist BC-105 (pizotifen; 3 mg/kg) but not by the dopamine (DA) antagonist haloperidol (0.1 mg/kg). It was abolished by pre-treatment with the 5-HT synthesis inhibitor p-chlorophenylalanine (100 mg/kg/day for 3 days). In addition, THBC was found to inhibit 3 H-LSD binding to homogenates of rat frontal cortex with an IC 50 value of 4 μM which is similar to that previously reported for other 5-HT agonists. These data indicate that THBCs exert potent 5-HT agonist actions. Since THBCs have recently been found in mammalian brain and other tissues, the present results are of interest in relation to a possible role of these substances in endogenous psychosis. |
| Databáze: | OpenAIRE |
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