Outcomes with percutaneous mitral repair vs. optimal medical treatment for functional mitral regurgitation: systematic review
| Autor: | Isaac Pascual, Antonio Adeba, Hector Cubero-Gallego, Jacobo Silva, Rebeca Lorca, Marcel Almendarez, Pablo Avanzas, Daniel Hernández-Vaquero, César Morís, Alain Escalera, José Rozado |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Medical treatment business.industry MitraClip 05 social sciences MEDLINE General Medicine 030204 cardiovascular system & hematology medicine.disease law.invention Surgery 03 medical and health sciences 0302 clinical medicine Systematic review medicine.anatomical_structure Randomized controlled trial law Heart failure Mitral valve 0502 economics and business medicine 050211 marketing business Functional mitral regurgitation |
| Zdroj: | WOS:000561888400026 RUO: Repositorio Institucional de la Universidad de Oviedo Universidad de Oviedo (UNIOVI) RUO. Repositorio Institucional de la Universidad de Oviedo instname |
| ISSN: | 2305-5847 2305-5839 |
| DOI: | 10.21037/atm.2020.03.202 |
| Popis: | Functional mitral regurgitation (MR) could be defined as a ventricular disease where mitral valve is structurally normal, left chambers are enlarged and mitral annulus is dilated with lack of coaptation of leaflets. Transcatheter mitral valve repair technique has broadened the therapeutic range in the treatment of severe MR. The aim of this study was to review outcomes of MitraClip vs. medical treatment for functional MR. We also planned to review the concept of functional MR, assessment of the degree, prognosis and therapy options. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Medline through PubMed database was used to search. The present review included manuscripts published between January 2009 and September 2019. Two authors independently screened titles and abstracts of all publications, and performed the selection of studies and data extraction. In the case of disagreements, consensus meetings reached the final decision. Inclusion criteria were: (I) randomized controlled trials and (II) works must compare MitraClip versus optimal medical treatment. Transcatheter mitral valve repair along optimal medical treatment has been compared with optimal medical therapy in two different randomized trials. In the COAPT trial, the MitraClip group showed a significant reduction in mortality and heart failure (HF) hospitalizations. In the MITRA-FR trial, no significant differences were observed between both groups. We reviewed important aspects of functional MR and performed a comprehensive review of both trials comparing them and focusing on their differences. |
| Databáze: | OpenAIRE |
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