Fractional Hypopituitarism with Giantism and Normal Sella Turcica
| Autor: | T. S. Danowski, George H. Fetterman, Margaret E. Sarver, George Sabeh, Niel Wald |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
medicine.medical_specialty
Pediatrics Statistics as Topic Thyroid Gland Function Tests Hypopituitarism Thyroid Function Tests Urine Growth hormone Gigantism Pallor Adrenocorticotropic Hormone Hypothyroidism Internal medicine medicine Fluids and Secretions Sella Turcica Mineralocorticoid Receptor Antagonists Chromosome Aberrations business.industry Hypogonadism General Medicine Ketones Metyrapone medicine.disease Endocrinology Sella turcica medicine.anatomical_structure Adrenal gland hypofunction Pituitary-Adrenal Function Tests medicine.symptom business Adrenal Insufficiency |
| Zdroj: | New England Journal of Medicine. 271:1286-1289 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | THREE patients under our care with giantism and a striking similarity of appearance (pallor, smooth skin and youthful mien in addition to large limbs, hands and feet) validate the suggestion of Goldman, Cahill and Thorn1 that this is a syndrome of fractional hypopituitarism. The syndrome, as described in the case reported by Goldman et al., consisted of hypogonadism, hypothyroidism and hypoadrenocorticism in addition to giantism stemming from normal or increased quantities or effects of growth hormone. Our observations establish that hypothyroidism is not an essential feature and expand the clinical experience with this syndrome. Clinical and Laboratory Findings The findings . . . |
| Databáze: | OpenAIRE |
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