Myoblast Cell Interaction with Polydopamine Coated Liposomes

Autor: Brigitte Städler, Rebecca van der Westen, Fernando Albericio, Kenneth N. Goldie, Almar Postma, Leticia Hosta-Rigau, Duncan S. Sutherland
Přispěvatelé: University of Zurich, Städler, Brigitte
Rok vydání: 2012
Předmět:
Indoles
Chemistry(all)
SX20 Research
Technology and Development Projects
Polymers
General Physics and Astronomy
1600 General Chemistry
Nanotechnology
Cell Communication
Physics and Astronomy(all)
engineering.material
General Biochemistry
Genetics and Molecular Biology
Cell Line
Myoblasts
Biomaterials
Mice
SX00 SystemsX.ch
Materials Science(all)
Coating
1300 General Biochemistry
Genetics and Molecular Biology
Animals
General Materials Science
Lipid bilayer
chemistry.chemical_classification
Liposome
Biochemistry
Genetics and Molecular Biology(all)
2502 Biomaterials
General Chemistry
Polymer
2500 General Materials Science
3100 General Physics and Astronomy
Endocytosis
Polymerization
chemistry
Liposomes
Drug delivery
SX03 CINA
engineering
Biophysics
570 Life sciences
biology
Surface modification
Biosensor
Zdroj: van der Westen, R, Rigau, L H, Sutherland, D S, Goldie, K, Alebericio, F, Postma, A & Stadler, B 2012, ' Myoblast Cell Interaction with Polydopamine Coated Liposomes ', Biointerphases, vol. 7, pp. 8 . https://doi.org/10.1007/s13758-011-0008-4
Scopus-Elsevier
ISSN: 1559-4106
1934-8630
DOI: 10.1007/s13758-011-0008-4
Popis: Liposomes are widely used, from biosensing to drug delivery. Their coating with polymers for stability and functionalization purposes further broadens their set of relevant properties. Poly(dopamine) (PDA), a eumelanin-like material deposited via the "self"-oxidative polymerization of dopamine at mildly basic pH, has attracted considerable interest in the past few years due to its simplicity, flexibility yet fascinating properties. Herein, we characterize the coating of different types of liposomes with PDA depending on the presence of oleoyldopamine in the lipid bilayer and the dopamine hydrochloride concentration. Further, the interaction of these coated liposomes in comparison to their uncoated counterparts with myoblast cells is assessed. Their uptake/association efficiency with these cells is determined. Further, their dose-dependent cytotoxicity with and without entrapped hydrophobic cargo (thiocoraline) is characterized. Taken together, the reported results demonstrate the potential of PDA coated liposomes as a tool in biomedical applications.
Databáze: OpenAIRE
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