Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population
| Autor: | Tarun Narang, Bashir A. Ganai, Tahseena Akhtar, Aadil Wani, Rajinder Kaur |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:QH426-470 medicine.medical_treatment Population Cytokine Polymorphism IL-20 ELISA Psoriasis Biology Pathogenesis 03 medical and health sciences 0302 clinical medicine Interleukin 20 Polymorphism (computer science) Psoriasis medicine education Genetics (clinical) lcsh:R5-920 education.field_of_study Haplotype medicine.disease lcsh:Genetics 030104 developmental biology Cytokine 030220 oncology & carcinogenesis Immunology Gene polymorphism lcsh:Medicine (General) |
| Zdroj: | Egyptian Journal of Medical Human Genetics, Vol 19, Iss 3, Pp 201-205 (2018) Egyptian Journal of Medical Human Genetics; Vol 19, No 3 (2018); 201–205 |
| ISSN: | 1110-8630 |
| DOI: | 10.1016/j.ejmhg.2017.09.002 |
| Popis: | Background : IL-20 plays an important role in the inflammatory and hyperproliferative dermatosis of psoriasis. Aim: The aim of the study was to determine whether the IL-20 gene polymorphism, haplotype and serum level confer pathogenesis of psoriasis. Subjects and methods : 200 psoriatic patients and 200 controls were genotyped for four IL-20 polymorphic sites by polymerase chain reaction. Serum levels of IL-20 were measured by ELISA. Results : Our results demonstrated that polymorphism of IL-120 1380 A/G (adjusted⁄ OR 5.52; (95% CI = 2.43–12.55) was found to be in association with increased risk of psoriasis while as IL-20–1462 G/A (adjusted⁄ OR = 0.11 95; (95% CI = 0.03–0.34) was found to be in association with decreased risk of psoriasis and IL-20–1053 G/T adjusted⁄ OR 1.99; (95% CI = 0.86–4.64), IL-20–3978 T/C(adjusted⁄ OR = 12.87; (95% CI = 0.97–79.54) polymorphism does not show any significant association with the risk of psoriasis. HT4 TG haplotype is associated with decreased risk of psoriasis. Serum IL-20 level significantly increases in patients, as compared to controls with non-significant correlation between serum IL-20 and psoriasis severity. Conclusion : These findings suggest that IL-20 polymorphism have significant role towards the susceptibility of psoriasis in north Indian population. Evaluating the role of IL-20 cytokine in pathogenesis of psoriasis will prove helpful for the development of psoriasis management. Keywords : Cytokine Polymorphism IL-20 ELISA Psoriasis |
| Databáze: | OpenAIRE |
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