Detrimental effects of prenatal exposure to filtered diesel exhaust on mouse spermatogenesis
| Autor: | Shigeru Oshio, Yuichiro Niwata, Isamu Sugawara, Hirohisa Takano, Naomi Tsukue, Naoka Ono, Seiichi Yoshida, Ken Takeda |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Diesel exhaust Time Factors 17-Hydroxysteroid Dehydrogenases Ratón medicine.drug_class Offspring Health Toxicology and Mutagenesis Biology Toxicology Giant Cells Mice Pregnancy Internal medicine Testis medicine Animals Testosterone RNA Messenger Particle Size Receptor Spermatogenesis Vehicle Emissions Mice Inbred ICR Sperm Count luteinizing hormone/choriogonadotropin receptor Steroid 17-alpha-Hydroxylase General Medicine Receptors LH Seminiferous Tubules Androgen Endocrinology Gene Expression Regulation Prenatal Exposure Delayed Effects Vacuoles Female |
| Zdroj: | Archives of toxicology. 82(11) |
| ISSN: | 1432-0738 |
| Popis: | We recently showed that prenatal exposure to diesel exhaust (DE) disrupts spermatogenesis in mouse offspring. This study was undertaken to determine whether filtered DE in which 99.97% of diesel exhaust particles >0.3 microm in diameter were removed affects spermatogenesis in growing mice. After prenatal exposure to filtered DE for 2-16 days postcoitum, we examined daily sperm production (DSP), testicular histology, serum testosterone levels and mRNA expression of hormone synthesis process-related factors. In the filtered DE exposed group, DSP was markedly reduced at 12 weeks compared with the control group; clean air exposed group. Histological examination showed multinucleated giant cells and partial vacuolation in the seminiferous tubules of the exposed group. Testosterone was elevated significantly at 5 weeks. Moreover, luteinizing hormone receptor mRNA at 5 and 12 weeks, 17alpha-hydroxylase/C17-20-lyase and 17beta-hydroxysteroid dehydrogenase mRNAs at 12 weeks were significantly elevated. These results suggest that filtered DE retains its toxic effects on the male reproductive system following prenatal exposure. |
| Databáze: | OpenAIRE |
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