Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Maxillary Sinus: A Case Report and Review of Literature
| Autor: | Monarchi Gabriele, Tullio Antonio, Giovacchini Francesco, Mitro Valeria, Sidoni Angelo, Caselli Emanuele |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Maxillary sinus Adenoma Pleomorphic Case Reports Pathology and Forensic Medicine Diagnosis Differential Pleomorphic adenoma 03 medical and health sciences Cytokeratin 0302 clinical medicine medicine Humans Neoplasm Neoplasm Staging Maxillary Neoplasms Salivary gland business.industry Carcinoma Myoepithelial cell Middle Aged medicine.disease Parotid gland 030104 developmental biology medicine.anatomical_structure Oncology Otorhinolaryngology 030220 oncology & carcinogenesis Immunohistochemistry business Paranasal Sinus Neoplasms |
| Zdroj: | Head Neck Pathol |
| ISSN: | 1936-0568 |
| DOI: | 10.1007/s12105-020-01282-5 |
| Popis: | Myoepithelial carcinoma ex pleomorphic adenoma is defined as a malignant epithelial neoplasm arising from a primary or recurrent benign pleomorphic adenoma. This type of tumor comprises 3.6% of all salivary gland tumors and 12% of malignant ones. Clinically, it most commonly presents as a firm mass in the parotid gland. The development of this neoplasm in the sinonasal and nasopharyngeal regions is extremely rare and only few cases are reported in the literature. The prognosis of myoepithelial carcinoma is variable. Marked cellular pleomorphism, high mitotic rate, and high proliferative activity correspond to a poor prognosis. In this article, the authors report the histopathological features of a clinical case of a 64-years-old patient with a large median maxillary neoplasm diagnosed as myoepithelial carcinoma/ex-pleomorphic adenoma. The tumor was resected and subjected to secondary reconstruction using a revascularized free fibula flap. The myoepithelial derivation of neoplastic cells was demonstrated by immunohistochemical positivity for S-100 protein (strong and diffuse), cytokeratin 14 (strong and diffuse), and GFAP (focal). |
| Databáze: | OpenAIRE |
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