Acute administration of haloperidol does not influence 123I-FP-CIT binding to the dopamine transporter
| Autor: | Kora de Bruin, Pieter Voorn, Guus van Loon, Jan Booij |
|---|---|
| Přispěvatelé: | Amsterdam Neuroscience, Nuclear Medicine, Anatomy and neurosciences, NCA - neurodegeneration |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Cerebellum medicine.medical_treatment Striatum Nucleus accumbens Nucleus Accumbens Dopamine Internal medicine medicine Haloperidol Animals Radiology Nuclear Medicine and imaging Rats Wistar Antipsychotic Saline Dopamine transporter Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins biology Chemistry Brain Rats Neostriatum Endocrinology medicine.anatomical_structure biology.protein Radiopharmaceuticals medicine.drug Antipsychotic Agents Tropanes |
| Zdroj: | Journal of nuclear medicine, 55(4), 647-649. Society of Nuclear Medicine Inc. Journal of Nuclear Medicine, 55(4), 647-649. Society of Nuclear Medicine Inc. Booij, J, van Loon, G, de Bruin, K & Voorn, P 2014, ' Acute Administration of Haloperidol Does Not Influence I-123-FP-CIT Binding to the Dopamine Transporter ', Journal of Nuclear Medicine, vol. 55, no. 4, pp. 647-649 . https://doi.org/10.2967/jnumed.113.132340 |
| ISSN: | 0161-5505 |
| DOI: | 10.2967/jnumed.113.132340 |
| Popis: | A recent 123I-FP-CIT (123-I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane) SPECT study on rats suggested that a single 1 mg/kg dose of the antipsychotic haloperidol induces enough dopamine release to compete with 123I-FP-CIT for binding to the dopamine transporter. Taking into account the far-reaching consequences of this proposition, we were interested in testing whether we could reproduce this finding using storage phosphor imaging. Methods: Twenty rats were pretreated with saline or haloperidol (1 mg/kg of body weight) and then injected with 123I-FP-CIT. Two hours after 123I-FP-CIT injection, the rats were sacrificed and binding in the striatum, nucleus accumbens, and cerebellum (nonspecific binding) was measured. Results: In contrast to the earlier SPECT finding, acute administration of haloperidol did not induce a significant change in 123I-FP-CIT binding ratios in the striatum and nucleus accumbens. Conclusion: Changes in synaptic dopamine due to acute haloperidol administration were not detectable with 123I-FP-CIT. |
| Databáze: | OpenAIRE |
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