New Steroidal Saponins Isolated from the Rhizomes of Paris mairei
| Autor: | Bang-Le Zhang, Yang Liu, Minchang Wang, Hai-Feng Tang, Peng-Cheng Qiu, Yun-Yang Lu, Hao He |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cell Survival
Paris mairei Pharmaceutical Science Chemical Fractionation Biology complex mixtures Article Analytical Chemistry Inhibitory Concentration 50 15-oxo-18-nor-spirost QD241-441 Genus Paris spirostane saponin Cell Line Tumor Drug Discovery parasitic diseases Humans Physical and Theoretical Chemistry Folk medicine steroidal saponins Molecular Structure Traditional medicine Plant Extracts Spectrum Analysis Organic Chemistry Phytosterols Saponins musculoskeletal system Rhizome carbohydrates (lipids) Chemistry (miscellaneous) Molecular Medicine cytotoxicity Melanthiaceae |
| Zdroj: | Molecules Volume 26 Issue 21 Molecules, Vol 26, Iss 6366, p 6366 (2021) |
| ISSN: | 1420-3049 |
| Popis: | The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A–E (1–5), along with five known steroidal saponins 6–10, were isolated from the rhizomes of Paris mairei. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines. |
| Databáze: | OpenAIRE |
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