Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling
| Autor: | Maike Svenja Schulz, Enno Klussmann, Ekaterina Perets, Alessandro Dema, Veronika Anita Deák |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
A-kinase-anchoring protein
Scaffold protein Molecular Sequence Data A Kinase Anchor Proteins Antineoplastic Agents Biology Bioinformatics Second Messenger Systems Protein–protein interaction chemistry.chemical_compound Neoplasms Cyclic AMP Animals Humans Cyclic adenosine monophosphate Amino Acid Sequence Molecular Targeted Therapy Protein Interaction Maps Protein kinase A Conserved Sequence Cardiovascular Agents Cell Biology Cyclic AMP-Dependent Protein Kinases Signalling chemistry Cardiovascular Diseases Second messenger system CAMP signalling Neuroscience |
| Zdroj: | Cellular Signalling. 27:2474-2487 |
| ISSN: | 0898-6568 |
| DOI: | 10.1016/j.cellsig.2015.09.008 |
| Popis: | The second messenger cyclic adenosine monophosphate (cAMP) can bind and activate protein kinase A (PKA). The cAMP/PKA system is ubiquitous and involved in a wide array of biological processes and therefore requires tight spatial and temporal regulation. Important components of the safeguard system are the A-kinase anchoring proteins (AKAPs), a heterogeneous family of scaffolding proteins defined by its ability to directly bind PKA. AKAPs tether PKA to specific subcellular compartments, and they bind further interaction partners to create local signalling hubs. The recent discovery of new AKAPs and advances in the field that shed light on the relevance of these hubs for human disease highlight unique opportunities for pharmacological modulation. This review exemplifies how interference with signalling, particularly cAMP signalling, at such hubs can reshape signalling responses and discusses how this could lead to novel pharmacological concepts for the treatment of disease with an unmet medical need such as cardiovascular disease and cancer. |
| Databáze: | OpenAIRE |
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