Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet

Autor: Anthony V. Perkins, Steven D. Melvin, Daniel R. McKeating, Olivia J. Holland, Deanne H. Hryciw, James S. M. Cuffe, Nirajan Shrestha, Andrew J. McAinch
Přispěvatelé: Shrestha, Nirajan [0000-0003-1259-0661], Holland, Olivia J [0000-0002-5798-5264], Cuffe, James SM [0000-0002-2675-8149], Perkins, Anthony V [0000-0002-9829-6772], McAinch, Andrew J [0000-0002-8762-4865], Hryciw, Deanne H [0000-0003-1697-8890], Apollo - University of Cambridge Repository
Rok vydání: 2021
Předmět:
Male
Metabolite
Lysine
Rats
Inbred WKY
chemistry.chemical_compound
Plasma
Pregnancy
Lactation
3-Hydroxybutyric Acid
Biology (General)
Spectroscopy
Acetic Acid
chemistry.chemical_classification
Principal Component Analysis
Sex Characteristics
food and beverages
General Medicine
humanities
Computer Science Applications
Chemistry
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Gestation
Adult Children
Female
Polyunsaturated fatty acid
linoleic acid
medicine.medical_specialty
QH301-705.5
Offspring
Linoleic acid
metabolite
Biology
Diet
High-Fat
Catalysis
Article
Inorganic Chemistry
Internal medicine
medicine
Animals
sex
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
offspring
Organic Chemistry
Maternal Nutritional Physiological Phenomena
Diet
Endocrinology
chemistry
Animals
Newborn
ROC Curve
Zdroj: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10223, p 10223 (2021)
ISSN: 1422-0067
Popis: Background: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required for foetal growth and development. Excess intake of LA can be detrimental for metabolic health due to its pro-inflammatory properties
however, the effect of a diet high in LA on offspring metabolites is unknown. In this study, we aimed to determine the role of maternal or postnatal high linoleic acid (HLA) diet on plasma metabolites in adult offspring. Methods: Female Wistar Kyoto (WKY) rats were fed with either low LA (LLA) or HLA diet for 10 weeks prior to conception and during gestation/lactation. Offspring were weaned at postnatal day 25 (PN25), treated with either LLA or HLA diets and sacrificed at PN180. Metabolite analysis was performed in plasma samples using Nuclear Magnetic Resonance. Results: Maternal and postnatal HLA diet did not alter plasma metabolites in male and female adult offspring. There was no specific clustering among different treatment groups as demonstrated by principal component analysis. Interestingly, there was clustering among male and female offspring independent of maternal and postnatal dietary intervention. Lysine was higher in female offspring, while 3-hydroxybutyric acid and acetic acid were significantly higher in male offspring. Conclusion: In summary, maternal or postnatal HLA diet did not alter the plasma metabolites in the adult rat offspring
however, differences in metabolites between male and female offspring occurred independently of dietary intervention.
Databáze: OpenAIRE
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