Chemokine-mediated tissue recruitment of CXCR3+ CD4+ T cells plays a major role in the pathogenesis of chronic GVHD
| Autor: | Jane Nunnick, Charles Craddock, Paul Moss, Charlotte F. Inman, Joanne E. Croudace, Prem Mahendra, Sandeep Nagra, Ram Malladi, Ben Abbotts |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
CD4-Positive T-Lymphocytes
Chemokine Receptors CXCR3 Transplantation Conditioning Immunology Graft vs Host Disease Biology CXCR3 Biochemistry Chemokine CXCL9 Pathogenesis immune system diseases hemic and lymphatic diseases CXCL10 Humans CXCL11 Hematopoietic Stem Cell Transplantation Cell Biology Hematology Dermis Chemokine CXCL11 Chemokine CXCL10 Haematopoiesis Arterioles Chemotaxis Leukocyte Hematologic Neoplasms Acute Disease biology.protein Disease Progression CXCL9 CD8 |
| Zdroj: | Blood. 120(20) |
| ISSN: | 1528-0020 |
| Popis: | Chemokines regulate the migration of hemopoietic cells and play an important role in the pathogenesis of many immune-mediated diseases. Intradermal recruitment of CD8+ T cells by CXCL10 is a central feature of the pathogenesis of cutaneous acute GVHD (aGVHD), but very little is known about the pathogenesis of chronic GVHD (cGVHD). Serum concentrations of the 3 CXCR3-binding chemokines, CXCL9, CXCL10, and CXCL11, were found to be markedly increased in patients with active cGVHD of the skin (n = 8). An 80% decrease in CD4+ cells expressing CXCR3 was seen in the blood of these patients (n = 5), whereas CD4+ cells were increased in tissue biopsies and were clustered around the central arterioles of the dermis. The well-documented increase in expression of CXCL10 in aGVHD therefore diversifies in cGVHD to include additional members of the CXCR3-binding family and leads to preferential recruitment of CD4+ T cells. These observations reveal a central role for chemokine-mediated recruitment of CXCR3+ T cells in cGVHD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|