Cardiothoracic Morphology Measures in Heart Failure Patients to Inform Device Designs
| Autor: | Ryan Lahm, James P Gaewsky, Bharathi Upadhya, Mona Saffarzadeh, Geoffrey T. Jao, Ashley A. Weaver, Joshua Tan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Pacemaker Artificial medicine.medical_specialty Sternum 0206 medical engineering Cardiac-Gated Imaging Techniques Biomedical Engineering Diastole 02 engineering and technology 030204 cardiovascular system & hematology Prosthesis Design Ventricular Function Left Article Electrocardiography 03 medical and health sciences Sex Factors 0302 clinical medicine Predictive Value of Tests Mitral valve Internal medicine Humans Medicine Aged Aged 80 and over Heart Failure Body surface area Ejection fraction business.industry Stroke Volume medicine.disease 020601 biomedical engineering Defibrillators Implantable medicine.anatomical_structure Heart failure Coronal plane Cohort Cardiology Female Heart-Assist Devices Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovasc Eng Technol |
| ISSN: | 1869-4098 1869-408X |
| DOI: | 10.1007/s13239-019-00436-z |
| Popis: | PURPOSE: Approximately 5.7 million people in the US are affected by congestive heart failure. This study aimed to quantitatively evaluate cardiothoracic morphology and variability within a cohort of heart failure patients for the purpose of optimally engineering cardiac devices for a variety of heart failure patients. METHODS: Co-registered cardiac-gated and non-gated chest computed tomography (CT) scans were analyzed from 20 heart failure patients (12 males; 8 females) who were primarily older adults (79.5±8.8 years). Twelve cardiothoracic measurements were collected and compared to study sex and left ventricular (LV) ejection fraction (EF) type differences in cardiothoracic morphology. RESULTS: Four measures were significantly greater in males compared to females: LV long-axis length, LV end diastolic diameter (LVEDD) at 50% length of the LV long-axis, the minimal distance between the sternum and heart, and the angle between the LV long-axis and coronal plane. Four measures were significantly greater in patients with reduced EF compared to preserved LV: LV long-axis length, LVEDD at 50% length of the LV long-axis, left ventricular volume normalized by body surface area, and the angle between the mitral valve plane and LV long-axis. CONCLUSIONS: These cardiothoracic morphology measurements are important to consider in the design of cardiac devices for heart failure management (e.g. cardiac pacemakers, ventricular assist devices, and implantable defibrillators), since morphology differs by sex and ejection fraction. |
| Databáze: | OpenAIRE |
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