Effects of renal denervation on cardiovascular, metabolic and renal functions in streptozotocin-induced diabetic rats
| Autor: | Michelle L. Garcia, Alex Yuri Simões-Sato, Gisele S. Lincevicius, Caroline Gusson Shimoura, Ruy R. Campos, Cássia T. Bergamaschi, Tales Lyra de Oliveira |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Glycosuria medicine.medical_specialty Sympathetic Nervous System Baroreceptor Renal function Blood Pressure Pressoreceptors Baroreflex Kidney Cardiovascular System 030226 pharmacology & pharmacy Streptozocin General Biochemistry Genetics and Molecular Biology Catheterization Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Sodium-Glucose Transporter 2 Heart Rate Internal medicine Diabetes mellitus medicine Animals Rats Wistar General Pharmacology Toxicology and Pharmaceutics Denervation Vasomotor business.industry Heart General Medicine medicine.disease Rats 030104 developmental biology Endocrinology medicine.anatomical_structure Hematocrit medicine.symptom business |
| Zdroj: | Life Sciences. 278:119534 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2021.119534 |
| Popis: | Diabetes promotes renal sympathetic hyperactivity, autonomic imbalance, and cardiovascular and renal dysfunction. Bilateral renal denervation (BRD) has emerged as a treatment for diabetes; however, the mechanisms that underlie the beneficial effects of BRD are unknown. Aims The present study evaluated the effects of BRD on autonomic, cardiovascular, metabolic, and renal function in streptozotocin-diabetic rats. Main methods Wistar rats were separated into three experimental groups: control (CTR), diabetic (DM), and diabetic that underwent BRD (DM BRD). BRD was performed two weeks after STZ-diabetes induction, the experiments were performed four weeks after DM induction. This study evaluated sympathetic vasomotor nerve activity in different territories (renal, lumbar and splanchnic), arterial baroreceptor reflex, metabolic and renal function. Key findings BRD significantly reduced glycemia, glycosuria, albuminuria, and SGLT2 gene expression in the kidney in DM rats. Renal sympathetic nerve activity (rSNA) was significantly increased and splanchnic sympathetic nerve activity (sSNA) was significantly decreased in DM rats, without changes in lumbar sympathetic nerve activity (lSNA). BRD was able to normalize sSNA and significantly increase lSNA in DM rats compared to control rats. Additionally, cardiac baroreceptor sensitivity was impaired in DM rats, and BRD significantly improved baroreflex sensitivity. Significance Our data suggest that renal nerves play an important role in autonomic, cardiovascular, and renal dysfunction in STZ-DM rats. Thus, sympathetic renal hyperactivity should be considered a possible therapeutic target in diabetic patients. |
| Databáze: | OpenAIRE |
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