Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization
| Autor: | Pawel Roszak, Jung-ok Heo, Bernhard Blob, Koichi Toyokura, Yuki Sugiyama, Maria Angels de Luis Balaguer, Winnie W. Y. Lau, Fiona Hamey, Jacopo Cirrone, Ewelina Madej, Alida M. Bouatta, Xin Wang, Marjorie Guichard, Robertas Ursache, Hugo Tavares, Kevin Verstaen, Jos Wendrich, Charles W. Melnyk, Yoshihisa Oda, Dennis Shasha, Sebastian E. Ahnert, Yvan Saeys, Bert De Rybel, Renze Heidstra, Ben Scheres, Guido Grossmann, Ari Pekka Mähönen, Philipp Denninger, Berthold Göttgens, Rosangela Sozzani, Kenneth D. Birnbaum, Yrjö Helariutta |
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| Přispěvatelé: | Institute of Biotechnology (-2009), University of Helsinki, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Organismal and Evolutionary Biology Research Programme, Plant Biology, Viikki Plant Science Centre (ViPS), Yrjö Helariutta / Principal Investigator, Roszak, Pawel [0000-0002-7822-494X], Heo, Jung-Ok [0000-0002-5088-6044], Blob, Bernhard [0000-0003-4269-7742], Toyokura, Koichi [0000-0001-7775-7886], Sugiyama, Yuki [0000-0002-5235-2943], Lau, Winnie WY [0000-0003-1209-1854], Hamey, Fiona [0000-0001-7299-2860], Madej, Ewelina [0000-0002-0729-0245], Bouatta, Alida M [0000-0001-9326-7561], Guichard, Marjorie [0000-0003-4417-3504], Tavares, Hugo [0000-0001-9373-2726], Verstaen, Kevin [0000-0003-3582-0298], Wendrich, Jos [0000-0002-6198-3763], Melnyk, Charles W [0000-0003-3251-800X], Oda, Yoshihisa [0000-0001-6934-4424], Shasha, Dennis [0000-0002-7036-3312], Ahnert, Sebastian E [0000-0003-2613-0041], Saeys, Yvan [0000-0002-0415-1506], De Rybel, Bert [0000-0002-9551-042X], Heidstra, Renze [0000-0001-9032-5770], Scheres, Ben [0000-0001-5400-9578], Grossmann, Guido [0000-0001-7529-9244], Mähönen, Ari Pekka [0000-0001-6051-866X], Denninger, Philipp [0000-0003-3794-2360], Göttgens, Berthold [0000-0001-6302-5705], Sozzani, Rosangela [0000-0003-3316-2367], Birnbaum, Kenneth D [0000-0002-8423-6859], Helariutta, Yrjö [0000-0002-7287-8459], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
EXPRESSION
Meristem Arabidopsis Phloem Plant Roots Article ROOT RHO GTP-Binding Proteins REVEALS Life Science Laboratorium voor Moleculaire Biologie RNA-SEQ RNA-Seq Multidisciplinary Arabidopsis Proteins REGULATORY NETWORK fungi 1184 Genetics developmental biology physiology Biology and Life Sciences food and beverages Cell Differentiation GENE GTPASES MORPHOGENESIS GROWTH Laboratory of Molecular Biology EPS Single-Cell Analysis Transcriptome Signal Transduction Transcription Factors |
| Zdroj: | SCIENCE Science Science 374 (2021) 6575 Science, 374(6575) |
| ISSN: | 0036-8075 1095-9203 |
| DOI: | 10.17863/cam.78815 |
| Popis: | Publisher Copyright: Copyright © 2021 The Authors, some rights reserved; In the plant meristem, tissue-wide maturation gradients are coordinated with specialized cell networks to establish various developmental phases required for indeterminate growth. Here, we used single-cell transcriptomics to reconstruct the protophloem developmental trajectory from the birth of cell progenitors to terminal differentiation in the Arabidopsis thaliana root. PHLOEM EARLY DNA-BINDING-WITH-ONE-FINGER (PEAR) transcription factors mediate lineage bifurcation by activating guanosine triphosphatase signaling and prime a transcriptional differentiation program. This program is initially repressed by a meristem-wide gradient of PLETHORA transcription factors. Only the dissipation of PLETHORA gradient permits activation of the differentiation program that involves mutual inhibition of early versus late meristem regulators. Thus, for phloem development, broad maturation gradients interface with cell-type-specific transcriptional regulators to stage cellular differentiation. |
| Databáze: | OpenAIRE |
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