Early dynamic 201Tl SPECT in the evaluation of brain tumours
| Autor: | Yoshikatsu Seiki, Toshiyuki Kano, Yoshinori Aoki, Chikao Miyazaki, Kousuke Kondo, Naoyuki Harada, Kyousuke Yokota, Masaaki Nemoto, Nobuo Sugo, Hitoshi Ohishi |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Time Factors chemistry.chemical_element Single-photon emission computed tomography Malignancy Sensitivity and Specificity Severity of Illness Index Meningioma Text mining Pituitary adenoma Glioma Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Thallium Aged Retrospective Studies Aged 80 and over Tomography Emission-Computed Single-Photon medicine.diagnostic_test Brain Neoplasms business.industry Reproducibility of Results General Medicine Middle Aged Image Enhancement medicine.disease chemistry Female Radiopharmaceuticals Nuclear medicine business Anaplastic astrocytoma |
| Zdroj: | Nuclear Medicine Communications. 27:143-149 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/01.mnm.0000191853.34574.3f |
| Popis: | Objective To estimate the usefulness of early dynamic 201 TI single photon emission computed tomography (SPECT) studies in distinguishing the histological malignancy of brain tumours. Methods Dynamic 201 TI SPECT was performed for 3 min per scan for 15 min immediately after the administration of 201 TICI in 110 patients with brain tumours (111 lesions). The data obtained each 3 min were used for dynamic SPECT, and the five sets of data obtained were added to acquire static SPECT data. For static SPECT, the static thallium index (STI) was calculated as the ratio of 201 TI uptake in the tumour to that of the contralateral normal brain. The ratio of the 201 TI uptake for each 3 min was defined as the dynamic thallium index (DTI). The dynamic thallium rate (DTR), as a per cent, was calculated as DTR = (DTI for every 3 min)/STI H 100. The five values were approximated as a linear function and the slope (%/min) was calculated. Results In static SPECT, there was no significant difference between the STI of malignant tumours (glioblastoma and anaplastic astrocytoma) and that of benign tumours (low-grade glioma, meningioma, pituitary adenoma, neurinoma and haemangioblastoma) (3.7 ± 1.5, 5.0 ± 3.5, respectively). On dynamic SPECT, DTI increased markedly over 15 min for malignant tumours. In contrast, the DTI of benign tumours increased slightly, steadily or decreased. The slope of the linear functions calculated from the DTRs was much higher in the malignant tumour group than in the benign tumour group (P< 0.001). Conclusions We suggest that the performance of 201 TI dynamic SPECT for 15 min is useful for distinguishing malignant brain tumours from benign brain tumours and reduces the examination stress of patients. |
| Databáze: | OpenAIRE |
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