Thymoma-associated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with Myasthenia Gravis
| Autor: | Jun-ichi Morita, Kousuke Miyake, Satoshi Kaneko, Hirofumi Kusaka, Satoshi Morise, Masataka Nakamura, Takenobu Kunieda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Thymoma Encephalomyelitis medicine.medical_treatment Case Report 030204 cardiovascular system & hematology progressive encephalomyelitis with rigidity and myoclonus Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Receptors Glycine hemic and lymphatic diseases Internal Medicine medicine stiff-person syndrome Humans Aged Autoantibodies myasthenia gravis business.industry Glutamate Decarboxylase glutamic acid decarboxylase General Medicine Thymus Neoplasms medicine.disease Thymectomy Myasthenia gravis nervous system diseases Muscle Rigidity Prednisolone Female medicine.symptom glycine receptor business Myoclonus 030217 neurology & neurosurgery Stiff person syndrome medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | We report a case of a 72-year-old woman who initially presented with symptoms of bulbar myasthenia and was positive for anti-acetylcholine receptor antibodies. She subsequently developed painful muscle spasms, myoclonus, and stiffness. Thymoma was detected, and both anti-glycine receptor and anti-glutamic acid decarboxylase antibodies were found. She was diagnosed with thymoma-associated progressive encephalomyelitis with rigidity and myoclonus (PERM). She experienced marked improvement after thymectomy followed by plasma exchange and intravenous immunoglobulin and prednisolone. This case suggests that thymectomy followed by sufficient immunosuppression may be useful in the treatment of thymoma-associated PERM. Myasthenia gravis may develop in thymoma-associated PERM patients. |
| Databáze: | OpenAIRE |
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