Platelet morphological indices on Intensive Care Unit admission predict mortality in septic but not in non-septic patients
| Autor: | Federico Franchi, Antonella Cotoia, Giulia Benetto, Iryna Kozhevnikova, Fabio Silvio Taccone, Sabino Scolletta, Carlo Alberto Volta, Savino Spadaro, Alberto Fogagnolo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Critical Illness Independent predictor law.invention NO Primary outcome Blood platelets law Internal medicine Sepsis Medicine Humans Clinical significance Platelet Mean platelet volume Mortality business.industry Critically ill Critical care bacterial infections and mycoses Intensive care unit Thrombocytopenia Icu admission Intensive Care Units Anesthesiology and Pain Medicine Cardiology business Mean Platelet Volume |
| Popis: | BACKGROUND Thrombocytopenia is associated with worse outcomes in critically ill patients. The clinical relevance of other platelets indices is less studied. We investigated the ability of the platelets distribution width (PDW) and the mean platelet volume (MPV) to predict mortality in critically ill patients. We hypothesized that the prognostic values of PDW and MPV could be different in septic and non-septic patients. METHODS We prospectively analyzed patients with an expected ICU length of stay ≥48 hours. Repeated measurements of PDW and MPV were considered (on ICU admission and up to day 5 thereafter). The primary outcome was to investigate the ability of PDW and MPV to predict 90-day mortality in septic and non-septic patients. RESULTS We included in the study 234 patients of which 31% patients were septic. 90-day mortality was 39% in septic and 27% non-septic patients. PDW and MPV values on admission were 12.5±2.5% and 10.7±1.1 fL, respectively. The AUROC of PDW values on admission to predict 90-day mortality in septic patients was 0.813, being higher than those in non-septic patients (0.550, P |
| Databáze: | OpenAIRE |
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