Acute interferon β-1b administration alters hypothalamic-pituitary-adrenal axis activity, plasma cytokines and leukocyte distribution in healthy subjects
Autor: | Bernhard Saller, Marion U. Goebel, M.S Exton, Manfred Schedlowski, V Pithan, V Limmroth, J Baase |
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Rok vydání: | 2002 |
Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Lymphocyte Hypothalamus Blood Pressure Body Temperature Placebos Norepinephrine (medication) Leukocyte Count Endocrinology Adjuvants Immunologic Heart Rate Internal medicine Adrenal Glands medicine Humans Biological Psychiatry Cross-Over Studies Interleukin-6 Tumor Necrosis Factor-alpha Endocrine and Autonomic Systems business.industry Interferon beta-1b Granulocytosis Interferon-beta Flow Cytometry medicine.disease Lymphocyte Subsets Recombinant Proteins Prolactin Interleukin-10 Kinetics Psychiatry and Mental health medicine.anatomical_structure Epinephrine Pituitary Gland Cytokines business Hypothalamic–pituitary–adrenal axis Glucocorticoid medicine.drug |
Zdroj: | Psychoneuroendocrinology. 27:881-892 |
ISSN: | 0306-4530 |
Popis: | It has been suggested that the immune-endocrine communication plays an important role in development and progression of multiple sclerosis (MS). Interferon beta (IFN beta-1b) treatment is the therapy of choice in patients suffering from relapsing remitting or secondary chronic progressive multiple sclerosis. While typical adverse events of IFN beta-1b treatment such as flu-like symptoms or fatigue are well studied, little is known about the acute changes in the immune and neuroendocrine system. Therefore, we analyzed the short-term effects of IFN beta-1b on cortisol, epinephrine, norepinephrine, prolactin and growth hormone (GH) plasma levels before and 4, 8 and 24 h after IFN beta-1b administration in healthy subjects. Moreover, we determined heart rate, blood pressure, body temperature, leukocyte and lymphocyte subsets and plasma levels of interleukin (IL)-1 beta, IL-6, IL-10 and tumor necrosis factor (TNF)-alpha. IFN beta-1b led to an increase in body temperature and heart rate, and in parallel, elevated cortisol, prolactin and GH plasma levels at 4 and 8 h after IFN beta-1b injection. There were no significant alterations in blood pressure, norepinephrine or epinephrine plasma levels. Simultaneously, IFN beta-1b injection led to an immediate granulocytosis while concomitantly decreasing peripheral lymphocytes, especially natural killer (NK) cells. At the same time, IL-6, IL-10 and TNF-alpha plasma levels showed an overall increase. Overall, cytokine administration exerts strong stimulatory effects on the hypothalamic-pituitary-adrenal (HPA)-axis that may contribute to the side effects of IFN beta-1b therapy and affect the efficacy of IFN beta-1b treatment. |
Databáze: | OpenAIRE |
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