Effects of Al3+ on Phosphocholine and Phosphoglycerol Containing Solid Supported Lipid Bilayers
| Autor: | Angelika Kunze, Lewis E. Johnson, Malkiat S. Johal, Marcus J. Swann, Hannah K. Wayment-Steele, Yujia Jing, Björn Agnarsson, Sofia Svedhem |
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| Rok vydání: | 2016 |
| Předmět: |
Phase transition
Phosphorylcholine Lipid Bilayers Molecular Conformation 02 engineering and technology Molecular Dynamics Simulation 01 natural sciences Diffusion chemistry.chemical_compound Molecular dynamics Phase (matter) 0103 physical sciences Electrochemistry Fluorescence microscope General Materials Science Lipid bilayer Spectroscopy Phosphocholine Birefringence 010304 chemical physics Surfaces and Interfaces Quartz crystal microbalance 021001 nanoscience & nanotechnology Condensed Matter Physics Crystallography chemistry Glycerophosphates 0210 nano-technology Aluminum |
| Zdroj: | Langmuir. 32:1771-1781 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/acs.langmuir.5b03999 |
| Popis: | Aluminum has attracted great attention recently as it has been suggested by several studies to be associated with increased risks for Alzheimer's and Parkinson's disease. The toxicity of the trivalent ion is assumed to derive from structural changes induced in lipid bilayers upon binding, though the mechanism of this process is still not well understood. In the present study we elucidate the effect of Al(3+) on supported lipid bilayers (SLBs) using fluorescence microscopy, the quartz crystal microbalance with dissipation (QCM-D) technique, dual-polarization interferometry (DPI), and molecular dynamics (MD) simulations. Results from these techniques show that binding of Al(3+) to SLBs containing negatively charged and neutral phospholipids induces irreversible changes such as domain formation. The measured variations in SLB thickness, birefringence, and density indicate a phase transition from a disordered to a densely packed ordered phase. |
| Databáze: | OpenAIRE |
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