Synthesis and Properties of Oligonucleotides Having Ethynylphosphonate Linkages

Autor:	Masahiko Horiba, Takao Yamaguchi, Satoshi Obika
Rok vydání:	2019
Předmět:	inorganic chemicals chemistry.chemical_compound chemistry Oligonucleotide Organic Chemistry Ribonuclease H Oligonucleotides DNA Single-Stranded RNA Oligonucleotides Antisense Thymidine Combinatorial chemistry
Zdroj:	The Journal of organic chemistry. 85(4)
ISSN:	1520-6904
Popis:	Ethynylphosphonate (EP)-linked thymidine dimers were synthesized via a palladium-catalyzed cross-coupling reaction and successfully incorporated into oligonucleotides. The oligonucleotides containing EP linkages appropriately formed a duplex with their complementary single-stranded RNA (ssRNA) and single-stranded DNA. The oligonucleotides containing both the EP linkages and 2'
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef48eb3ef12ed1f546d2908ecd050511 https://pubmed.ncbi.nlm.nih.gov/31867976 Zobrazit plný text záznamu