Potency requirements of rabies vaccines administered intradermally using the Thai Red Cross regimen: investigation of the immunogenicity of serially diluted purified chick embryo cell rabies vaccine
| Autor: | Karel Honegr, Jiri Beran, Claudius Malerczyk, Angelika Banzhoff |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Adolescent Injections Intradermal Rabies Immunoglobulins Chick Embryo medicine.disease_cause Antibodies Viral Rabies vaccine Antigen Chlorocebus aethiops medicine Potency Animals Humans Vero Cells Vaccines Synthetic General Veterinary General Immunology and Microbiology business.industry Immunogenicity Rabies virus Public Health Environmental and Occupational Health medicine.disease Virology Regimen Infectious Diseases Vaccine Potency Rabies Vaccines Molecular Medicine Biological Assay business medicine.drug |
| Zdroj: | Vaccine. 23(30) |
| ISSN: | 0264-410X |
| Popis: | To determine the minimum vaccine potency per intradermal dose required to elicit an adequate immune response using the Thai Red Cross (TRC) regimen (2-2-2-0-1-1), healthy volunteers received 0.1 mL volumes of PCECV containing decreasing amounts of antigen. Subjects also received HRIG to evaluate potential interference with antibody production. Results indicated that when each 0.1 mL intradermal dose of PCECV contained antigen corresponding to 0.32 IU per intramuscular dose, every subject had titers above 0.5 IU/mL by day 14. These results confirm that the current World Health Organization (WHO) recommendations for vaccine potency (2.5 IU per intramuscular dose) are sufficient for use in the Thai Red Cross intradermal regimen. |
| Databáze: | OpenAIRE |
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