Laminar pattern of mineral calcium-phosphorus deposits in a human carotid plaque: nanoscale ultrastructure and elemental analysis
| Autor: | Franca Marino, Matteo Tozzi, Sergio Lecchini, Marco Cosentino, Ramona Consuelo Maio, Carlo Dell'Orbo, Achille Venco, Luana Castiglioni, Terenzio Congiu, Daniela Elena Quacci, Lorenzo Maroni, Luigina Guasti, Anna Maria Grandi, Laura Schembri, Patrizio Castelli |
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| Rok vydání: | 2010 |
| Předmět: |
Calcium Phosphates
Male Context (language use) Mineralization (biology) chemistry.chemical_compound Calcinosis Physiology (medical) medicine Humans Carotid Stenosis Aged Mineral business.industry Cholesterol Spectrometry X-Ray Emission Anatomy medicine.disease Carotid Arteries chemistry Elemental analysis Microscopy Electron Scanning Biophysics Ultrastructure Crystallization Cardiology and Cardiovascular Medicine business Calcification |
| Popis: | Atherosclerotic calcifications are related to poor prognosis and all-cause mortality in large population studies.1 Moreover, vascular calcifications are inversely associated with the potential reduction of plaque volume in regression studies during statin treatment, which suggests that more calcified lesions are less likely to undergo positive remodeling.2 Recently, it has been suggested that calcification is a tightly regulated process of mineralization akin to bone formation.3 In plaques, the deposits consist of a nonhomogeneous composite that contains hydroxyapatite mineral nanocrystals embedded in a collagenous organic matrix, whereas at a nanoscale level, apatite crystals interact with cholesterol crystallites. In this context, mineralization may result from a basic template pattern generated by the organic … |
| Databáze: | OpenAIRE |
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