Angiogenin promotes colorectal cancer metastasisviatiRNA production
| Autor: | Ningqin Xu, Muxiong Chen, Xiaoliang Shi, Rongpan Bai, Kefeng Ding, Haiyan Chen, Jinghao Sheng, Siqi Li, Desen Sun, Zhengping Xu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research Angiogenin Colorectal cancer Mice Nude Mice SCID Metastasis Gene Knockout Techniques Mice 03 medical and health sciences 0302 clinical medicine RNA Transfer Downregulation and upregulation Cell Movement Mice Inbred NOD In vivo medicine Animals Humans Neoplasm Invasiveness Clinical significance Neoplasm Metastasis neoplasms Mice Inbred BALB C Neovascularization Pathologic business.industry SUPERFAMILY Ribonuclease Pancreatic medicine.disease digestive system diseases In vitro Up-Regulation Oncology Case-Control Studies 030220 oncology & carcinogenesis Colonic Neoplasms Cancer research Heterografts 5' Untranslated Regions business |
| Zdroj: | International Journal of Cancer. 145:1395-1407 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.32245 |
| Popis: | Metastasis of colorectal cancer (CRC) is the leading cause of CRC-associated mortality. Angiogenin (ANG), a member of the ribonuclease A superfamily, not only activates endothelial cells to induce tumor angiogenesis, but also targets tumor cells to promote cell survival, proliferation and/or migration. However, its clinical significance and underlying mechanism in CRC metastasis are still largely unknown. Here, we reported that ANG was upregulated in CRC tissues and associated with metastasis in CRC patients. We then revealed that ANG enhanced CRC growth and metastasis in both in vitro and in vivo systems. Intriguingly, we characterized a bunch of tRNA-derived stress-induced small RNAs (tiRNAs), produced through ANG cleavage, that was enriched in both CRC tumor tissues and highly metastatic cells, and functioned in ANG-promoted CRC metastasis. Moreover, higher level of a 5'-tiRNA from mature tRNA-Val (5'-tiRNA-Val) was observed in CRC patients and was correlated with tumor metastasis. Taken together, we propose that a novel ANG-tiRNAs-cell migration and invasion regulatory axis promotes CRC metastasis, which might be of potential target for CRC diagnosis and treatment. |
| Databáze: | OpenAIRE |
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