Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche
| Autor: | Veeramac Prasad, Preneet Cheema Brar, Raphael David, Daniela Ovadia, Elena Dingle, Sarah Pivo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism Anti-mullerian hormone 030209 endocrinology & metabolism Reference range 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Adrenarche Androge Testosterone Polycystic ovary syndrome 030219 obstetrics & reproductive medicine biology business.industry lcsh:RJ1-570 Anti-Müllerian hormone Bone age lcsh:Pediatrics Androgen Polycystic ovary Endocrinology Pediatrics Perinatology and Child Health biology.protein Original Article business Body mass index |
| Zdroj: | Annals of Pediatric Endocrinology & Metabolism, Vol 23, Iss 4, Pp 210-214 (2018) Annals of Pediatric Endocrinology & Metabolism |
| ISSN: | 2287-1292 2287-1012 |
| Popis: | Purpose Premature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5-8 years) and age and body mass index (BMI) matched controls. Methods Retrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done. Results PA girls (n=76) were matched to control girls (n=12) for age (mean±standard deviation) (6.7±1 years vs. 6.2±1.3 years) and BMI (20±10 kg/m2 vs. 17.8±2.7 kg/m2). Dehydroepiandrostenedione sulfate (63.3±51.3 μg/dL vs. 29.8±17.3 μg/dL, Pl0.001) and testosterone levels (11.4±4.8 ng/dL vs. 8.2±2.9 ng/dL, P=0.001) were significantly higher in the PA group than controls. AMH values (l14 years: reference range, 0.49-3.15 ng/mL) were 3.2±2.2 ng/mL vs. 4.6± 3.2 ng/mL respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were 39.5±30.5 ng/dL vs. 36.8±19.8 ng/dL in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups. Conclusion Higher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed. |
| Databáze: | OpenAIRE |
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