Genivir (DIP-253) 1% cream versus placebo cream in the treatment of recurrent genital herpes: a double-blind study
| Autor: | A Dahlgren, A Lassus, K Linnavuori |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Recurrent genital herpes Administration Topical Dermatology Placebo Placebo group Antiviral Agents Double blind study 03 medical and health sciences 0302 clinical medicine Double-Blind Method Heterocyclic Compounds Recurrence Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Group trial 030505 public health Herpes Genitalis Viral culture business.industry Public Health Environmental and Occupational Health Herpes virus culture Infectious Diseases Active agent Vaginal Creams Foams and Jellies Female 0305 other medical science business |
| Zdroj: | International journal of STDAIDS. 1(1) |
| ISSN: | 0956-4624 |
| Popis: | A total of 100 heterosexual adults of either sex with frequent episodes of recurrent genital herpes were allocated to treatment with either Genivir (DIP-253) 1% cream or placebo cream. All patients had genital herpes previously verified by a positive viral culture. The study was carried out as a double-blind parallel group trial. Fifty patients were allocated to each of the two treatment groups. The treatment was initiated within 24 hours after the first sign of a recurrence, and at the pre-treatment examination all patients had developed typical lesions with blisters and/or sores. At baseline a sample for herpes virus culture and typing was obtained. The creams were applied four times daily for five days. Follow-up examinations were carried out on days 1, 2, 4 and if needed on days 7, 10 and 14. The major factor used for assessment of efficacy was the time to complete healing of all lesions. Duration of pruritus and pain were also recorded. In the group of patients treated with Genivir cream the time to complete healing was 3.3 days and in the placebo group 6.1 days. The difference was statistically significant ( P |
| Databáze: | OpenAIRE |
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