Endotoxemia in Peritoneal Dialysis Patients: A Pilot Study to Examine the Role of Intestinal Perfusion and Congestion
| Autor: | Eleanor F. Cox, Carolyn Costigan, Caroline L. Hoad, Cheuk-Chun Szeto, Charlotte Buchanan, Ka-Bik Lai, Penny A. Gowland, Christopher W. McIntyre, Claire J Grant, Susan T. Francis, Luca Marciani, Laura E. A. Harrison |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology Magnetic Resonance Imaging Cine Pilot Projects 030204 cardiovascular system & hematology Gastroenterology Statistics Nonparametric Peritoneal dialysis 03 medical and health sciences 0302 clinical medicine Peritoneal Dialysis Continuous Ambulatory Reference Values Internal medicine medicine Humans Dialysis Aged Heart Failure Intestinal perfusion business.industry Role General Medicine Middle Aged medicine.disease Endotoxemia Surgery Endotoxins Perfusion Survival Rate Treatment Outcome Nephrology Case-Control Studies Kidney Failure Chronic Female Hemodialysis business Kidney disease |
| Zdroj: | Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 37:111-115 |
| ISSN: | 1718-4304 0896-8608 |
| Popis: | Endotoxemia is common in advanced chronic kidney disease and is particularly severe in those receiving dialysis. In hemodialysis patients, translocation from the bowel occurs as a consequence of recurrent circulatory stress leading to a reduction in circulating splanchnic volume and increased intestinal permeability. Peritoneal dialysis (PD) patients are often volume expanded and have continuous direct immersion of bowel in fluid; these may also be important factors in endotoxin translocation and would suggest different therapeutic strategies to improve it. The mechanisms leading to endotoxemia have never been specifically studied in PD. In this study, 17 subjects (8 PD patients, 9 healthy controls) underwent detailed gastrointestinal and cardiac magnetic resonance imaging during fasted and fed states. Gross splanchnic perfusion was assessed by quantification of superior mesenteric artery flow. Magnetic resonance imaging findings were correlated to endotoxemia, markers of hydration status and cardiac structure and function. |
| Databáze: | OpenAIRE |
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