Spectral domain optical coherence tomography-based prevalence of hydroxychloroquine maculopathy in Indian patients on hydroxychloroquine therapy: A utopia of underdiagnosis
| Autor: | Poninder Kumar, Sumedha Vats, P.S. Moulick, Shikha Pandey |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures 030106 microbiology Spectral domain Article Spectral domain optical coherence tomography 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Ophthalmology Maculopathy Prevalence Medicine In patient 030212 general & internal medicine medicine.diagnostic_test business.industry Hydroxychloroquine General Medicine medicine.disease eye diseases Visual field sense organs business medicine.drug |
| Zdroj: | Medical Journal, Armed Forces India |
| ISSN: | 0377-1237 |
| Popis: | Background Spectral domain optical coherence tomography (SD-OCT) detects early structural damage to macula in patients on Hydroxychloroquine (HCQ) therapy. The current screening protocols emphasize concurrent use of both SD-OCT and Visual field analysis (VFA) which detects functional damage to detect Hydroxychloroquine maculopathy. However, VFA is a time-consuming and subjective test which is often neglected. This study gives the prevalence of Hydroxychloroquine maculopathy using SD-OCT alone which often fails to detect macular damage in peri-foveal and extra-foveal area of the retina. Methods Three hundred thirty four eyes of 167 patients taking systemic Hydroxychloroquine were studied with SD-OCT macular cube 512 x 128 to diagnose structural macular damage to detect prevalence of Hydroxychloroquine maculopathy. Results Out of 167 patients, only four patients showed features suggestive of Hydroxychloroquine maculopathy. One patient had ELM loss, two had para-foveal and one had peri-foveal IS-OS disruption. The SD-OCT gave prevalence as 2.4%. Conclusion SD-OCT alone can underdiagnose burden of Hydroxychloroquine maculopathy (prevalence = 2.4%) when compared to studies which use both SD-OCT and Visual field analysis (prevalence = 7.5%). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect