Grade groups at diagnosis in African Caribbean men with prostate cancer: Results of a comparative study
| Autor: | Thierry Lebret, Vincent Vinh-Hung, Willy Sutter, Vincent Molinié, Hervé Baumert, Juliet Tantot, François Martin, Touafik Taouil, Matthias E Meunier, Yann Neuzillet, Véronique Dussaule-Duchatelle, Maxime Vignac, T. Ghoneim |
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| Přispěvatelé: | Radiation Therapy, Translational Radiation Oncology and Physics |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Paris medicine.medical_specialty Multivariate analysis Prostate biopsy Biopsy West Indies Urology Black People White People 03 medical and health sciences Prostate cancer 0302 clinical medicine Transcriptional Regulator ERG Risk Factors Internal medicine medicine Humans Stage (cooking) Pathological Aged Retrospective Studies Univariate analysis medicine.diagnostic_test business.industry Prostatic Neoplasms Middle Aged Prostate-Specific Antigen Prognosis medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cohort Neoplasm Grading business Martinique |
| Zdroj: | The Prostate. 79:1640-1646 |
| ISSN: | 1097-0045 0270-4137 |
| Popis: | BACKGROUND: There are no comparative data on pathological predictors at diagnosis, between African Caribbean and Caucasian men with prostate cancer (PCa), in equal-access centers. The objective of this study was to evaluate the grade groups of an African Caribbean cohort, newly diagnosed with PCa on prostate biopsy, compared with a Caucasian French Metropolitan cohort. METHODS: A retrospective, a comparative study was conducted between 2008 and 2016 between the University Hospital of Martinique in the French Caribbean West Indies, and the Saint Joseph Hospital in Paris. Clinical, biological, and pathological data were collected at diagnosis. The primary outcome was the grade groups for Gleason score; the secondary outcome was the PCa detection rate. Multivariate analysis was performed using linear regression. RESULTS: Of the 1880 consecutive prostate biopsy performed in the African Caribbean cohort, 945 had a diagnosis of PCa (50.3%) and 500 of 945 in the French cohort (33.8%). African Caribbean patients were older (mean 68.5 vs 67.5 years; P = .028), had worse clinical stage (13.2% vs 5.2% cT3-4; P |
| Databáze: | OpenAIRE |
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