Alternative (backdoor) androgen production and masculinization in the human fetus
| Autor: | Siladitya Bhattacharya, Bruno Le Bizec, Olle Söder, Iuliia Savchuk, Ugo Soffientini, Denise Hough, Zoe C. Johnston, Panagiotis Filis, Michelle Bellingham, Paul Fowler, Peter J. O'Shaughnessy, Marie-Line Morvan, Jean-Philippe Antignac, Natasha Walker, Ana Monteiro, Konstantin Svechnikov |
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| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Fetus Androsterone medicine.drug_class 030209 endocrinology & metabolism Placental insufficiency Biology urologic and male genital diseases medicine.disease Androgen 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine SRD5A1 medicine.anatomical_structure Endocrinology chemistry CYP17A1 Internal medicine Placenta medicine Genital tubercle 030304 developmental biology |
| Popis: | Masculinization of the external genitalia in humans is dependent on formation of 5α-dihydrotestosterone (DHT) through both the canonical androgenic pathway and an alternative (backdoor) pathway. The fetal testes are essential for canonical androgen production but little is known about the synthesis of backdoor androgens despite their known critical role in masculinization. In this study, we have measured plasma and tissue levels of endogenous steroids in second trimester human male fetuses using multi-dimensional and high-resolution mass-spectrometry. Results show that androsterone is the principal backdoor androgen in the fetal circulation and that DHT is undetectable ( |
| Databáze: | OpenAIRE |
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