Dynamic Changes in Soluble Interleukin-2 Receptor Levels after Lung or Heart-Lung Transplantation
| Autor: | Nelson Dl, E. C. Lawrence, Michael E. DeBakey, George P. Noon, H. H. Whisennand, James B. Young, Brousseau Kp, N. T. Windsor, V. A. Holland |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Graft Rejection Male Pulmonary and Respiratory Medicine Interleukin 2 medicine.medical_specialty Heart-Lung Transplantation Infections Gastroenterology Sepsis Postoperative Complications Internal medicine medicine Humans Prospective Studies Receptor Clinical Trials as Topic Lung business.industry Respiratory disease Receptors Interleukin-2 Middle Aged medicine.disease Transplantation medicine.anatomical_structure Solubility Immunology Heart Transplantation Female Complication business Lung Transplantation medicine.drug |
| Zdroj: | American Review of Respiratory Disease. 140:789-796 |
| ISSN: | 0003-0805 |
| Popis: | Activation of T-lymphocytes is accompanied by the release of interleukin-2 receptors (IL-2R) in a soluble form that can be measured as an index of the activation process. We performed a prospective, blinded study of the dynamic changes in soluble IL-2R levels in serum in 12 patients undergoing lung or heart-lung transplantation. The levels of soluble IL-2R were markedly elevated during episodes of rejection (geometric mean value X divided by SEM = 3,770 X divided by 1.06 versus 411 X divided by 1.08 U/ml for normal controls, p less than 0.0001). Levels of soluble IL-2R were 2,105 X divided by 1.16 U/ml with rejection episodes in single lung recipients versus 5,560 X divided by 1.30 in recipients of two lungs (p = 0.005). Soluble IL-2R levels were 1,468 X divided by 1.05 during episodes of nonbacterial infections, 1,879 X divided by 1.34 with bacterial infections, and 5,056 X divided by 1.08 with sepsis (p less than 0.001 for each category compared to normals). Levels of soluble IL-2R exceeded 6,750 U/ml only with rejection episodes and were greater than 4,100 U/ml either with rejection, clinical sepsis, or overwhelming bacterial infection. We conclude that marked elevations of soluble IL-2R are associated with rejection, intermediate elevations with either rejection or infection, and that low levels of soluble IL-2R exclude rejection. |
| Databáze: | OpenAIRE |
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