Correlation of mammographic appearance and molecular prognostic factors in high-grade breast carcinomas
| Autor: | Likaki - Karatza Eleni, Ravazoula Panagiota, Androutsopoulos Georgios, Michail Georgios, Batistatou Anna, Tzorakoleftherakis Evaggelos, Kalofonos Haralabos, Kourounis Georgios |
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| Předmět: |
Adult
Receptor ErbB-2 Gene Expression Regulation Neoplastic mammographic appearance Mammography Breast Neoplasms Receptors Progesterone/analysis Cathepsin D Sensitivity and Specificity Cohort Studies Biomarkers Tumor Carcinoma Intraductal Noninfiltrating/genetics/*metabolism/*pathology Humans breast carcinoma Molecular Biology Aged Neoplasm Staging Tumor Markers Biological/analysis Breast Neoplasms/genetics/*metabolism/*pathology Biopsy Needle Cathepsin D/metabolism Receptor erbB-2/metabolism Middle Aged Genes p53 Prognosis Immunohistochemistry Carcinoma Intraductal Noninfiltrating Proto-Oncogene Proteins c-bcl-2 Receptors Estrogen molecular prognostic factors Female Proto-Oncogene Proteins c-bcl-2/metabolism Receptors Estrogen/metabolism Receptors Progesterone |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| Popis: | The aim of our study was to evaluate the association between the mammographic appearance and the biologic characteristics of high-grade breast carcinomas. Three hundred and twenty patients with breast carcinomas were studied. Histological examination showed 83 (26%) high-grade ductal carcinomas. Immunohistochemistry was carried out by using antibodies against estrogen receptor (ER), progesterone receptor (PR), HER-2/neu, p53 and cathepsin D. In 60/83 high-grade carcinomas we studied the mammographic appearance. Asymmetric density with poorly defined margins without microcalcifications was the major mammographic finding in 49/60 (approximately 82%) high-grade ductal carcinomas. HER-2/neu positivity (68.7%) and p53 positivity (48.2%) were statistically correlated with asymmetric density with poorly defined margins without microcalcifications in high-grade carcinomas. We observed loss of ER and PR receptors in 50%, whereas loss of PR receptors was observed in 65% of high-grade breast carcinomas. Cathepsin D (> 20%) was detected in 38.5% of high-grade carcinomas. Our findings suggest a significant relationship between mammographic appearance and biologic markers in high-grade breast carcinomas. Eur J Gynaecol Oncol |
| Databáze: | OpenAIRE |
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