The mechanism of degeneration of striatal neuronal subtypes in Huntington disease

Autor: Nasir Rizvi, Adnan Maqsood Choudhry, Zia Choudhry, Huma Ikram, Nusrat Jahan Mobassarah, Azadeh A Rikani, Sagun Tulli
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Annals of Neurosciences
ISSN: 0976-3260
0972-7531
Popis: The pattern of neurodegeneration in Huntington’s disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In the striatum, medium spiny GABA neurons (MSN) are preferentially degenerate while others are relatively spared. Vulnerability of specific neuronal populations within the striatum to pathological events constitutes an important hallmark of degeneration in HD. In an attempt to explain a likely mechanism of degeneration of striatal neuronal populations in HD, possible causes underlying differential vulnerability of neuronal subtypes to excitoxic insults and neurotrophic factors are discussed in this paper.
Databáze: OpenAIRE