New Pharmacotherapy Targeting Cognitive Dysfunction of Schizophrenia via Modulation of GABA Neuronal Function
| Autor: | Tomiki Sumiyoshi, Masayoshi Kurachi, Takashi Uehara |
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| Rok vydání: | 2015 |
| Předmět: |
Agonist
medicine.drug_class glutamate 5-HT1A agonist Inhibitory postsynaptic potential Article gamma-Aminobutyric acid GABA Glutamatergic cognitive dysfunction mental disorders medicine Animals Humans Pharmacology (medical) Prefrontal cortex gamma-Aminobutyric Acid Pharmacology Psychotropic Drugs biology General Medicine medicine.disease schizophrenia Psychiatry and Mental health nervous system Neurology Schizophrenia T-817MA Receptor Serotonin 5-HT1A Excitatory postsynaptic potential biology.protein neuroprotection Schizophrenic Psychology Neurology (clinical) Cognition Disorders Psychology Neuroscience Parvalbumin medicine.drug |
| Zdroj: | Current Neuropharmacology |
| ISSN: | 1570-159X |
| DOI: | 10.2174/1570159x13666151009120153 |
| Popis: | Schizophrenia is considered a neurodevelopmental and neurodegenerative disorder. Cognitive impairment is a core symptom in patients with the illness, and has been suggested a major predictor of functional outcomes. Reduction of parvalbumin (PV)-positive γ-aminobutyric acid (GABA) interneurons has been associated with the pathophysiology of schizophrenia, in view of the link between the abnormality of GABA neurons and cognitive impairments of the disease. It is assumed that an imbalance of excitatory and inhibitory (E-I) activity induced by low activity of glutamatergic projections and PV-positive GABA interneurons in the prefrontal cortex resulted in sustained neural firing and gamma oscillation, leading to impaired cognitive function. Therefore, it is important to develop novel pharmacotherapy targeting GABA neurons and their activities. Clinical evidence suggests serotonin (5-HT) 1A receptor agonist improves cognitive disturbances of schizophrenia, consistent with results from preclinical studies, through mechanism that corrects E-I imbalance via the suppression of GABA neural function. On the other hand, T-817MA, a novel neurotrophic agent, ameliorated loss of PV-positive GABA neurons in the medial prefrontal cortex and reduction of gamma-band activity, as well as cognitive dysfunction in animal model of schizophrenia. In conclusion, a pharmacotherapy to alleviate abnormalities in GABA neurons through 5-HT1A agonists and T-817MA is expected to prevent the onset and/or progression of schizophrenia. |
| Databáze: | OpenAIRE |
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