History of vigorous leisure-time physical activity and early onset amyotrophic lateral sclerosis (ALS), data from the national ALS registry: 2010–2018
| Autor: | Bryn Davis, Pam Factor-Litvak, Paul Mehta, Jaime Raymond, Kevin Horton, Ted Larson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Adolescent Leisure time Physical activity Article 03 medical and health sciences Leisure Activities 0302 clinical medicine Early adulthood Humans Medicine Registries Amyotrophic lateral sclerosis Exercise Early onset business.industry Amyotrophic Lateral Sclerosis food and beverages Middle Aged medicine.disease Cross-Sectional Studies Neurology lipids (amino acids peptides and proteins) Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Amyotroph Lateral Scler Frontotemporal Degener |
| ISSN: | 2167-9223 2167-8421 |
| Popis: | BACKGROUND: Previous research has suggested that vigorous physical activity (VPA) during adolescence and early adulthood is associated with ALS. The National ALS Registry (Registry) collects physical activity data from persons with ALS. OBJECTIVE: To examine the association between vigorous VPA and early onset ALS, defined as a diagnosis before age 60, among patients enrolled in the Registry. VPA was defined as engaging in dynamic exercise for at least 10 minutes in a session that caused heavy sweating or large increases in breathing or heart rate. METHODS: A cross-sectional study was conducted of 5,463 ALS patients with VPA history and 956 ALS patients who never engaged in VPA. Patient characteristics were collected via online surveys in the following areas: demographic, lifetime VPA history, and initial onset of symptoms. General linear modeling was used to estimate mean age of diagnosis and to compute 95% confidence intervals. RESULTS: Patients who reported engaging in VPA at least moderately (three times a week) during early adulthood were more likely to have an ALS diagnosis earlier compared to patients who did not (p |
| Databáze: | OpenAIRE |
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