Depigmentation therapies in vitiligo
| Autor: | Rashmi Kumari, Divya Gupta, Devinder Mohan Thappa |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 4-methoxy phenol depigmentation therapy Vitiligo Cryotherapy Imiquimod Skin Pigmentation Dermatology Lasers Solid-State Cryosurgery Melanoma Vaccine monobenzyl ether of hydroquinone Depigmentation lcsh:Dermatology Medicine Humans vitiligo universalis Diphencyprone Phenol business.industry Cosmesis lcsh:RL1-803 medicine.disease Infectious Diseases Imatinib mesylate medicine.symptom business lasers medicine.drug |
| Zdroj: | Indian Journal of Dermatology, Venereology and Leprology, Vol 78, Iss 1, Pp 49-58 (2012) |
| ISSN: | 0973-3922 |
| Popis: | Depigmentation therapy in vitiligo is an option in those with extensive vitiligo who have failed to respond to medical therapy and have obvious cosmetic disfigurement due to intervening patchy pigmented areas. Various aspects of this therapy such as the cost, treatment time, course, permanency of depigmentation, side effects, and the possibility of repigmentation should first be discussed with the patient. At present, there is no ideal depigmenting therapy available, but many agents in the market have been in use for many years. Monobenzyl ether of hydroquinone (MBEH) is the mainstay and Food and Drug Administration (FDA) approved in USA but takes many months to depigment and is associated with local side effects and risk of repigmentation. Other agents which are also used are 4-methoxy phenol and 88% phenol. Physical therapies for depigmentation include Q-switched ruby and alexandrite lasers and cryotherapy. Second-line agents which can be explored for depigmentation include imatinib mesylate, imiquimod, and diphencyprone. Many possible experimental agents are being explored like various phenol derivatives, melanoma vaccines, interferon gamma, busulfan, etc. A major lacuna still exists in this area and a lot more research is desirable to give satisfactory cosmesis to these patients with extensive vitiligo. |
| Databáze: | OpenAIRE |
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