Apoptosis-induced lymphopenia in sepsis and other severe injuries
| Autor: | Thibaut Girardot, Fabienne Venet, Guillaume Monneret, Thomas Rimmelé |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Apoptosis Lymphocyte apoptosis Sepsis 03 medical and health sciences 0302 clinical medicine Immune system Lymphopenia Immune Tolerance Humans Medicine In patient Lymphocytes Pharmacology business.industry Biochemistry (medical) 030208 emergency & critical care medicine Immunosuppression Cell Biology medicine.disease Clinical Practice 030104 developmental biology Severe trauma Immunology Burns business |
| Zdroj: | Apoptosis. 22:295-305 |
| ISSN: | 1573-675X 1360-8185 |
| DOI: | 10.1007/s10495-016-1325-3 |
| Popis: | Sepsis and other acute injuries such as severe trauma, extensive burns, or major surgeries, are usually followed by a period of marked immunosuppression. In particular, while lymphocytes play a pivotal role in immune response, their functions and numbers are profoundly altered after severe injuries. Apoptosis plays a central role in this process by affecting immune response at various levels. Indeed, apoptosis-induced lymphopenia duration and depth have been associated with higher risk of infection and mortality in various clinical settings. Therapies modulating apoptosis represent an interesting approach to restore immune competence after acute injury, although their use in clinical practice still presents several limitations. After briefly describing the apoptosis process in physiology and during severe injuries, we will explore the immunological consequences of injury-induced lymphocyte apoptosis, and describe associations with clinically relevant outcomes in patients. Therapeutic perspectives targeting apoptosis will also be discussed. |
| Databáze: | OpenAIRE |
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