Open randomized trial of the effects of 6% hydroxyethyl starch 130/0.4/9 and 5% albumin on safety profile, volume efficacy, and glycocalyx degradation in hepatic and pancreatic surgery
| Autor: | Kaoru Koyama, Toshinari Suzuki |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Plasma Substitutes Urology Hemodynamics Hydroxyethyl starch Glycocalyx Hydroxyethyl Starch Derivatives 03 medical and health sciences symbols.namesake chemistry.chemical_compound 0302 clinical medicine 030202 anesthesiology Albumins medicine Humans Fisher's exact test Creatinine business.industry Albumin 030208 emergency & critical care medicine Perioperative Anesthesiology and Pain Medicine chemistry Anesthesia symbols Fluid Therapy Isotonic Solutions business Abdominal surgery medicine.drug |
| Zdroj: | Journal of Anesthesia. 34:912-923 |
| ISSN: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s00540-020-02847-y |
| Popis: | The aim of this study was to evaluate the effects of hydroxyethyl starch (HES) 130/0.4/9 compared to 5% albumin on renal and coagulation safety profiles, volume efficacy and glycocalyx degradation in major abdominal surgery. The study was approved by the institutional ethics committee as a single center, open-labeled randomized trial. Fifty patients undergoing hepatic or pancreatic surgery were randomly assigned to the HES group (n = 25), who received HES 130/0.4/9, or the Albumin group (n = 25), who received 5% albumin. Ringer’s acetate solution (3 ml/kg/h) and colloid solution (2 mL/kg/h) were infused and goal-directed fluid management was performed to stabilize hemodynamics. Perioperative changes and differences in serum creatinine, N-acetyl-beta-d-glucosaminidase (NAG), hemodynamics, coagulation parameters and glycocalyx biomarkers were compared between the groups. Blood loss and requirements for transfusion and vasoactive agents were also examined. Statistical analysis was performed by Mann–Whitney U tests, chi-square or Fisher exact test, with P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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