Antiarrhythmic and electrophysiological effects of CH-200
| Autor: | Tokumasa Tsukada, Keitaro Hashimoto, Shoichi Imai, Hiroto Matsuda |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Lidocaine Action Potentials Pyridinium Compounds Procainamide Pharmacology Membrane Potentials Dogs Heart Rate Internal medicine Heart rate medicine Animals Ligation business.industry Coronary ligation Effective refractory period Acetophenones Arrhythmias Cardiac Coronary Vessels Myocardial Contraction Electric Stimulation Ventricular pacemaker Electrophysiology Cardiology Female business Anti-Arrhythmia Agents Microelectrodes medicine.drug |
| Zdroj: | European Journal of Pharmacology. 45:185-194 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(77)90088-7 |
| Popis: | A new antiarrhythmic drug CH-200, 5-phenacyl-thieno[3,2-c]pyridinium, was compared with procainamide and lidocaine in a two-stage coronary ligation arrhythmia model for its efficacy and electrophysiological properties. CH-200 suppressed arrhythmia in beagle dogs more effectively than did procainamide and lidocaine. The antiarrhythmic effects of CH-200 and procainamide developed slowly and lasted longer than those of lidocaine. Electrophysiological studies with CH-200 showed that it decreased max dV/dt of the action potential. This effect was dependent on the heart rate: the higher the rate, the stronger the effect. CH-200, procainamide and lidocaine prolonged the effective refractory period and this effect seemed to be responsible for suppressing the arrhythmia after coronary ligation. CH-200 and procainamide increased the frequency of ventricular pacemaker activity, 3hile lidocaine decreased it. These effects appear to be unimportant for hte antiarrhythmic effects. |
| Databáze: | OpenAIRE |
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