Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor

Autor:	Craig A. Smith, Kenneth H. Grabstein, Ben A. Falk, Tim VandenBos, Elizabeth Baker, Grant R. Sutherland, Kathryn B. Hennen, Rita Jerzy, Terry Farrah, Teresa W. Tough, Terri Davis-Smith, David Cosman, Richard J. Armitage, Judith G. Giri, Raymond G. Goodwin, M. Patricia Beckmann, Mark R. Alderson, Michael A. Schoenborn
Rok vydání:	1993
Předmět:	Antigens Differentiation T-Lymphocyte Cytotoxicity Immunologic Recombinant Fusion Proteins T-Lymphocytes Molecular Sequence Data Biology Vascular endothelial growth inhibitor Ligands General Biochemistry Genetics and Molecular Biology Epitope Cell Line Gene product Antigens CD Humans Amino Acid Sequence Cloning Molecular Receptors Immunologic B-cell activating factor Gene Library B-Lymphocytes CD40 Base Sequence Sequence Homology Amino Acid Tumor Necrosis Factor-alpha Chromosome Mapping Membrane Proteins DNA Fusion protein Molecular biology Transmembrane protein Immunoglobulin Fc Fragments Tumor Necrosis Factor Receptor Superfamily Member 7 Kinetics Oligodeoxyribonucleotides Immunoglobulin G Multigene Family biology.protein Cytokines Tumor necrosis factor alpha Chromosomes Human Pair 19 CD27 Ligand T-Lymphocytes Cytotoxic
Zdroj:	Cell. 73(3)
ISSN:	0092-8674
Popis:	CD27 is a surface antigen found on T and B cells that has homology to a family of molecules including the receptors for tumor necrosis factor (TNF) and nerve growth factor. A cDNA encoding a ligand for CD27 was isolated by a direct-expression cloning strategy using a fusion protein composed of the extracellular domain of CD27 linked to the constant domain of a human immunoglobulin G1 molecule as a probe. The predicted protein product is a type II transmembrane protein whose gene maps to 19p13 and that shows homology to TNF and the ligand for CD40. Biological characterization indicates that the cloned ligand induces the proliferation of costimulated T cells and enhances the generation of cytolytic T cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2ec87cb3fc2163af36bc56f7f5e258 https://pubmed.ncbi.nlm.nih.gov/8387892 Zobrazit plný text záznamu